37038-10-1

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 107-07-3 2-chloro-ethanol 

Downstream Products

• 1236970-07-2 1-(bis(2-azidoethoxy)methyl)-4-methoxybenzene 
• 37003-28-4 {2-[(2-Diethylamino-ethoxy)-(4-methoxy-phenyl)-methoxy]-ethyl}-diethyl-amine 

Relevant academic research and scientific papers

Nanoparticles and nanoparticle compositions

The invention provides multivalent surface-crosslinked micelle (SCM) particles, crosslinked reverse micelle (CRM) particles, and methods of making and using them. The SCM particles can be used, for example, to inhibit a virus or bacteria from binding to a host cell. The inhibition can be used in therapy for the flu, cancer, or AIDS. The CRM particles can be used, for example, to prepare metal nanoparticles or metal alloy nanoparticles, or they can be used in catalytic reactions.

NANOPARTICLES AND NANOPARTICLE COMPOSITIONS

The invention provides multivalent surface-crosslinked micelle (SCM) particles, crosslinked reverse micelle (CRM) particles, and methods of making and using them. The SCM particles can be used, for example, to inhibit a virus or bacteria from binding to a host cell. The inhibition can be used in therapy for the flu, cancer, or AIDS. The CRM particles can be used, for example, to prepare metal nanoparticles or metal alloy nanoparticles, or they can be used in catalytic reactions.

Rapid release of entrapped contents from multi-functionalizable, surface cross-linked micelles upon different stimulation

Hydrophobic guests such as pyrene could be readily trapped inside the micelles of an alkynylated surfactant in the presence of an azide-functionalized cross-linker using the click reaction. The cross-linker was designed to contain cleavable bonds such as geminal diol, disulfide, and acetal. The resulting pyrene-containing water-soluble nanoparticle was under electrostatic stress when diluted below the CMC of the surfactant. Extremely rapid (1 min) release of the hydrophobic content was observed when the cross-linker was cleaved. This method combines the ease of physical entrapment and the precision of chemical ligation, and potentially is highly useful in the delivery and controlled release of pharmaceutical agents.