3704-41-4

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
2-(4-Nitrophenyl)thiazole is used as a building block for the synthesis of various pharmaceuticals and agrochemicals, leveraging its potential biological activities to develop new therapeutic agents and pesticides.
Used in Biomedical Research:
2-(4-Nitrophenyl)thiazole is used as a fluorescent probe in biological imaging and diagnostic applications, taking advantage of its unique optical properties to enhance the visualization and detection of biological processes and structures.
Used in Materials Science:
2-(4-Nitrophenyl)thiazole is utilized in the design and development of organic electronic materials and devices, capitalizing on its electronic properties to create innovative materials for use in various electronic applications.

Upstream product

• 1826-11-5 2-phenylthiazole 
• 288-47-1 1,3-thiazole 
• 3466-32-8 4-bromoohenyl methyl sulfone 
• 2227-79-4 benzenecarbothioamide 
• 456-27-9 4-nitrobenzenediazonium tetrafluoroborate 
• 586-78-7 para-nitrophenyl bromide 
• 389630-95-9 (thiazol-2-yl)boronic acid 
• 3034-53-5 2-bromo-1,3-thiazole 
• 24067-17-2 4-nitrophenylboronic acid 
• 619-72-7 4-nitrobenzonitrile 
• 2518-13-0 2-(4-nitrophenyl)-4,5-dihydro-1,3-thiazole 

Downstream Products

• 193017-26-4 2-(4-Aminophenyl)thiazole 
• 25020-24-0 1-(4-methoxy-phenyl)-3-(4-thiazol-2-yl-phenyl)-thiourea 
• 25020-25-1 1-(4-ethoxy-phenyl)-3-(4-thiazol-2-yl-phenyl)-thiourea 
• 25020-38-6 1-(3,4-dichloro-phenyl)-3-(4-thiazol-2-yl-phenyl)-thiourea 
• 25020-27-3 1-(4-isopropoxy-phenyl)-3-(4-thiazol-2-yl-phenyl)-thiourea 
• 25020-26-2 1-(4-propoxy-phenyl)-3-(4-thiazol-2-yl-phenyl)-thiourea 
• 25020-36-4 1-(3-bromo-4-methoxy-phenyl)-3-(4-thiazol-2-yl-phenyl)-thiourea 
• 25020-28-4 1-(4-butoxy-phenyl)-3-(4-thiazol-2-yl-phenyl)-thiourea 
• 25020-37-5 1-(3-bromo-4-ethoxy-phenyl)-3-(4-thiazol-2-yl-phenyl)-thiourea 
• 185245-02-7 2-(4-Nitro-phenyl)-thiazole-5-carbaldehyde 

Relevant academic research and scientific papers

Identification of Piperidine-3-carboxamide Derivatives Inducing Senescence-like Phenotype with Antimelanoma Activities

This study evaluated the potential use of senescence-inducing small molecules in the treatment of melanoma. We screened commercially available small-molecule libraries with high-throughput screening and high-content screening image-based technology. Our findings showed an initial hit with the embedded N-arylpiperidine-3-carboxamide scaffold-induced senescence-like phenotypic changes in human melanoma A375 cells without serious cytotoxicity against normal cells. A focused library containing diversely modified analogues were constructed and examined to evaluate the structure-activity relationship of N-arylpiperidine-3-carboxamide derivatives starting from hit 1. This work identified a novel compound with remarkable antiproliferative activity in vitro and demonstrated the key structural moieties within.

RAD51 INHIBITORS

This application is directed to inhibitors of RAD51, and methods for their use, such as to treat or prevent conditions involving mitochondrial defects.

A new face of phenalenyl-based radicals in the transition metal-free C-H arylation of heteroarenes at room temperature: Trapping the radical initiator: Via C-C σ-bond formation

The radical-mediated transition metal-free approach for the direct C-H bond functionalization of arenes is considered as a cost effective alternative to transition metal-based catalysis. An organic ligand-based radical plays a key role by generating an aryl radical which undergoes a subsequent functionalization process. The design principle of the present study takes advantage of a relatively stable odd alternant hydrocarbon-based phenalenyl (PLY) radical. In this study, the first transition metal-free catalyzed direct C-H arylation of a variety of heteroarenes such as azoles, furan, thiophene and pyridine at room temperature has been reported using a phenalenyl-based radical without employing any photoactivation step. This protocol has been successfully applied to the gram scale synthesis of core moieties of bioactive molecules. The phenalenyl-based radical initiator has been characterized crystallographically by trapping it via the formation of a C-C σ-bond between the phenalenyl radical and solvent-based radical species.

Programmed synthesis of arylthiazoles through sequential C-H couplings

A programmed synthesis of privileged arylthiazoles via sequential C-H couplings catalyzed by palladium or nickel catalysts has been accomplished. This versatile protocol can supply all possible arylthiazole substitution patterns (2-aryl, 4-aryl, 5-aryl, 2

DDQ-induced dehydrogenation of heterocycles for c-c double bond formation: Synthesis of 2-thiazoles and 2-oxazoles

Strong as an Ox: 2-Thiazoles and 2-oxazoles are formed by oxidation of 2-thiazolines and 2-oxazolines without requiring substituents at the C4 and C5 positions. DDQ plays an important role as the oxidant in this transformation and metal is unnecessary. This general procedure shows good functional group tolerance and provides a wide variety of 2-thiazoles and 2-oxazoles in moderate to excellent yields.

ANTIFUNGAL AGENTS

Compounds of formula (I), and pharmaceutically acceptable salts thereof, may be used in therapy, for example as antifungal agents: (I) wherein: Rl, R2, R3, R4, R5, R6, R7, X and X1 are as defined herein. Certain compounds of formula (I) are also provided. Compounds of formula (T), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.