37040-43-0

Usage

Uses

Used in Pharmaceutical Research and Development:
3-[2-NITRO-4-(TRIFLUOROMETHYL)ANILINO]PROPANOIC ACID is used as a starting material for the synthesis of various drugs and pharmaceuticals, leveraging its unique chemical structure to contribute to the development of novel therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, 3-[2-NITRO-4-(TRIFLUOROMETHYL)ANILINO]PROPANOIC ACID serves as a key intermediate, facilitating the creation of complex organic molecules for a range of applications.
Used in Medicine:
3-[2-NITRO-4-(TRIFLUOROMETHYL)ANILINO]PROPANOIC ACID is utilized in the medical field for its potential applications in drug discovery, where its specific properties may contribute to the treatment or management of various health conditions.
Used in Agriculture:
In agricultural applications, 3-[2-NITRO-4-(TRIFLUOROMETHYL)ANILINO]PROPANOIC ACID may be employed as a component in the development of agrochemicals, such as pesticides or herbicides, due to its chemical reactivity and stability.
Used in Material Science:
3-[2-NITRO-4-(TRIFLUOROMETHYL)ANILINO]PROPANOIC ACID is also used in material science for its potential to enhance or create new materials with specific properties, such as improved stability or reactivity, for use in various industries.

InChI:InChI=1/C10H9F3N2O4/c11-10(12,13)6-1-2-7(8(5-6)15(18)19)14-4-3-9(16)17/h1-2,5,14H,3-4H2,(H,16,17)/p-1

Upstream product

• 121-17-5 2-chloro-3-nitro-5-trifluoromethylbenzene 
• 107-95-9 3-amino propanoic acid 

Downstream Products

• 168045-73-6 Ethyl 3-(2-nitro-4-trifluoromethylphenylamino)propionate 
• 106484-66-6 3-(2-Amino-4-trifluoromethyl-phenylamino)-propionic acid 

Relevant academic research and scientific papers

2,3(1H,4H)quinoxalinedione

2,3(1H,4H)-quinoxalinediones of the formula I STR1 where R1 is hydrogen, an aliphatic radical which has up to 12 carbons and can be substituted by one of the following: phenyl, cyclopentyl, cyclohexyl or --CO--R3, --CO--O--R3 or --CO--NH--R3, where R3 is hydrogen, C1 -C4 -alkyl, phenyl, benzyl or 1-phenylethyl, a cycloaliphatic radical with up to 12 carbons or phenyl, where the cyclic groups in R1 can have up to three of the following substituents: C1 -C4 -alkyl, C1 -C4 -haloalkyl, C1 -C4 -alkoxy, C1 -C4 -haloalkoxy, halogen, nitro, cyano, --CO--O--R3 and --CO--NH--R3 ; R2 is 1-pyrrolyl which can have up to two of the following substituents: C1 -C4 -alkyl, phenyl, phenylsulfonyl, nitro, cyano and --CO--O--R3, --CO--NH--R3, --CH2 --O--R3, --O--R3 and --CH=NO--R3 R radicals are identical or different and are the following: C1 -C4 -alkyl, C1 -C4 -alkoxy, trifluoromethyl, trichloromethyl, trifluoromethoxy, trichloromethoxy, fluorine, chlorine, bromine, iodine, nitro, cyano and --CO--O--R3 and --CO--NH--R3 as well as a fused-on benzene ring; n is 0-3, and 2,3(1H,4H)-quinoxalinediones I' STR2 where R1 has the stated meanings, are suitable as drugs in the treatment of neurodegenerative disorders and neurotoxic disturbances of the central nervous system.

Pyrrolylquinoxalinediones: A new class of AMPA receptor antagonists

Pyrrolylquinoxalinediones were synthesized and their affinities for the AMPA receptor were determined. Most compounds showed moderate to good affinities. The acetic acid derivative 8b exhibited a K(i) value of 70 nM and was equipotent to NBQX 1. Structure activity relationships are discussed. Selected compounds were tested for their potency to inhibit AMPA induced lethal convulsions in mice. In this in vivo model the compounds showed improved potency compared with NBQX.