37041-35-3

Basic information

• Product Name: Quinoline, 6-methoxy-3-phenyl-
• CAS NO: 37041-35-3
• Molecular Formula: C16H13NO
• Molecular Weight: 235.285
• Mol File: 37041-35-3.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: Quinoline, 6-methoxy-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Quinoline, 6-methoxy-3-phenyl-(37041-35-3)
• EPA Substance Registry System: Quinoline, 6-methoxy-3-phenyl-(37041-35-3)

Safety Data

• Hazardous Substances Data: 37041-35-3(Hazardous Substances Data)

Upstream product

• 1570-95-2 2-phenylpropane-1, 3-diol 
• 104-94-9 4-methoxy-aniline 
• 5669-11-4 3-oxo-2,3-diphenylpropanal 
• 26831-52-7 2-amino-5-methoxybenzaldehyde 
• 96-09-3 styrene oxide 
• 20357-24-8 5-methoxy-2-nitro-benzaldehyde 
• 122-78-1 phenylacetaldehyde 
• 55414-72-7 (2-amino-5-methoxyphenyl)methanol 
• 100-52-7 benzaldehyde 
• 67-68-5 dimethyl sulfoxide 
• 1006-94-6 5-methoxylindole 
• 4460-46-2 3-chloro-3-phenyl-3H-diazirine 
• 1670-14-0 benzamidine monohydrochloride 
• 122528-39-6 5-methoxybenzo[c]isoxazole? 

Relevant articles and documents

Method for preparing 3 - arylquinoline

The invention discloses a method for preparing 3 - arylquinoline, which is carried out in an oxygen-containing atmosphere, ortho-amine arylmethanol and aryl formaldehyde in DMSO-solution system containing an alkali to obtain 3 -arylquinoline compounds. In 3 - arylquinoline compound structure prepared by the method, 2 carbon atoms are provided by DMSO, aryl groups at 3 carbon atoms and 3 positions are provided by aryl formaldehyde, and all other atoms in the quinoline compound structure are provided by raw material o-amido aryl methanol. The method for synthesizing 3 - arylquinoline has the advantages of wide raw material sources, environmental friendliness, low price and simple operation, and is beneficial to industrial production.

Unexpected Annulation between 2-Aminobenzyl Alcohols and Benzaldehydes in the Presence of DMSO: Regioselective Synthesis of Substituted Quinolines

An unexpected annulation among 2-aminobenzyl alcohols, benzaldehydes, and DMSO to quinolines has been disclosed. For the reported annulation between 2-aminobenzyl alcohols and benzaldehydes, the change of the solvent from toluene to DMSO led to the change of the product from the diheteroatomic cyclic benzoxazines to monoheteroatomic cyclic quinolines. This annulation can be used to synthesize regioselectively different substituted quinolines by the choice of different 2-amino alcohols, aldehydes, and sulfoxides as substrates. Interestingly, introducing substituent groups to the α-position of sulfoxides resulted in the interchange of the positions between benzaldehydes and sulfoxides in the product quinolines. On the basis of the control experiments and literatures, a plausible mechanism for this annulation was proposed.

Method for synthesizing quinoline derivatives

The invention discloses a method for synthesizing quinoline derivatives. 2,1-benzisoxazole derivatives represented by formula I and phenylacetaldehyde derivatives represented by formula II are used as raw materials, and are reacted to obtain the quinoline