370565-64-3

Basic information

• Product Name: Benzenepropanoic acid, a-diazo-2-methyl-b-[[(4-methylphenyl)sulfonyl]amino]-, ethyl ester
• CAS NO: 370565-64-3
• Molecular Formula: C19H21N3O4S
• Molecular Weight: 387.459
• Mol File: 370565-64-3.mol

Chemical Properties

• CAS DataBase Reference: Benzenepropanoic acid, a-diazo-2-methyl-b-[[(4-methylphenyl)sulfonyl]amino]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, a-diazo-2-methyl-b-[[(4-methylphenyl)sulfonyl]amino]-, ethyl ester(370565-64-3)
• EPA Substance Registry System: Benzenepropanoic acid, a-diazo-2-methyl-b-[[(4-methylphenyl)sulfonyl]amino]-, ethyl ester(370565-64-3)

Safety Data

• Hazardous Substances Data: 370565-64-3(Hazardous Substances Data)

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 343598-64-1 N-(2-methylphenyl)methylidene-4-methylbenzenesulfonamide 
• 73845-01-9 N-[(E)-2-methylphenylmethylidene]-4-methylbenzenesulfonamide 

Relevant articles and documents

Investigation of the transition-metal- and acid-catalyzed reactions of β-(N-tosyl)amino diazo carbonyl compounds

A series of β-(N-tosyl)amino diazo carbonyl compounds have been prepared by nucleophilic condensation of N-tosylimines with acyldiazomethanes. The diazo decomposition of these diazo carbonyl compounds under various catalytic conditions, including Rh(II) carboxylates, Cu(I) and Cu(II) complexes, PhCO2Ag/Et3N, TsOH, and SnCl2·2H2O, has been investigated. It was found that, in most cases, the diazo decomposition gave preferentially 1,2-aryl migration product, but 1,2-hydride migration predominated when PhCO2Ag/Et3N was the catalytic system. Hammett correlation has been applied in the analysis of the electronic effects of 1,2-aryl migration. The factors that govern the migratory preference and the mechanistic aspects of the reaction are discussed.

DBU-promoted condensation of acyldiazomethanes to aldehydes and imines under catalytic conditions

The condensation of acyldiazomethanes to aldehydes and imines can be promoted with catalytic amount of DBU. The condensation gives β-hydroxy α-diazo carbonyl compounds or β-amino α-diazo carbonyl compounds in high yields.

1,2-aryl and 1,2-hydride migration in transition metal complex catalyzed diazo decomposition: A novel approach to α-aryl-β-enamino esters

matrix presented R = H, Me N-Tosyl diazoketamines were prepared by addition of the ethyl α-diazoacetate anion to N-sulfonylimines. The diazo decomposition of the diazoketamines with Rh2(OAc)4 complex resulted in aryl migration to giv