37059-79-3

Upstream product

• 56737-24-7 diphenylmethyl 7β-(thiophen-2-acetamido)-3-<(2-methyl-1,3,4-thiadiazol-5-yl)thiomethyl>-ceph-3-em-4-carboxylate 

Downstream Products

• 99909-10-1 7β-<(E)-α-(4-nitrobenzyloxycarbonylhydrazono)phenylacetamido>-3-<(5-methyl-1,3,4-thiadiazol-2-yl)thiomethyl>-3-cephem-4-carboxylic acid 
• 158497-34-8 diphenylmethyl 7β-<(Z)-2-(2-tert-butoxycarbonylaminothiazol-4-yl)-2-pentenoylamino>-3-(2-methyl-1,3,4-thiadiazol-5-ylthio)methyl-3-cephem-4-carboxylate 
• 99909-11-2 benzhydryl 7β-<(E)-α-(4-nitrobenzyloxycarbonylhydrazono)phenylacetamido>-3-<(5-methyl-1,3,4-thiadiazol-2-yl)thiomethyl>-3-cephem-4-carboxylate 

Relevant academic research and scientific papers

Synthesis and in vitro antimicrobial activity of 3-heteroarylsulphonylmethyl cephems: a new class of cephalosporins

A series of 3-heteroarylsulphonylmethyl and 3-heteroarylsulphenylmethyl cephems were prepared and tested for antimicrobial activities.In contrast to the adverse effect of oxidized ring sulphur of penams and cephems on antimicrobial activities, the oxidized side-chain sulphur of 3-mercaptoheteroaryl cephems retained Gram-negative and slightly decreased Gram-positive activity.The chemical nature of the moieties substituted at C-7 and C-3 positions also influenced the antibacterial activity and spectrum.Compounds with thienyl substitution at C-7 and sulphonylmethylthiazoles or sulphonylmethylthiadiazoles at C-3 exhibited good differentials in antibacterial activity versus their unoxidized counterparts. β-lactam / 3-heteroarylsulphonylcephem / oxidized cephem / antibacterial agent

3-Heterothio-7-ureido cephalosporins

Compounds of the formula STR1 wherein R1 is hydrogen, lower alkyl, cycloalkyl, cycloalkenyl, cycloalkadienyl, phenyl, phenyl-lower alkyl and substituted phenyl and phenyl-lower alkyl; R2 is hydrogen or lower alkyl; R3 is h

3-Heterothio substituted 7-(ureido-heteroacetyl) cephalosporins

Compounds of the formula STR1 wherein R1 and R4 represent certain heterocyclic groups; R2 is hydrogen or lower alkyl; and R3 is hydrogen, lower alkyl, phenyl-lower alkyl, substituted phenyl-lower alkyl, diphenyl

3-Heterothio[(thioalkyl)thioacetyl]cephalosporanic derivatives

3-Heterothio[(thioalkyl)thioacetyl]cephalosporin derivatives which have the formula STR1 wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, tri(lower alkyl)silyl, a salt forming ion, or the group STR2 R 1 is hydrogen, lower alkyl, phenyl, thienyl of furyl; R2 and R6 each is hydrogen or lower alkyl; R3 and R5 each is lower alkyl, phenyl or phenyl-lower alkyl; and R4 is a five- or six-membered nitrogen and/or sulfur or oxygen-containing ring system; are useful as antibacterial agents.

3-Heterothiomethyl-7α-methoxy-7β-tetrazolylmethylthioacetamido-3-cephem derivatives

7α-Methoxy-7β-tetrazolylmethylthioacetamido-3-cephem derivatives which have a heterothiomethyl substituent in the 3-position are novel compounds which are useful as antimicrobial agents.

3-Heterothio[(oxyalkyl)thioacetyl]cephalosporin derivatives

3-Heterothio[(oxyalkyl)thioacetyl] cephalosporin derivatives which have the formula EQU1 wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, tri (lower alkyl) silyl, a salt forming ion, or the group EQU2 R1 is hydrogen, lower alkyl, phenyl, thienyl or furyl; R2 and R6 each is hydrogen or lower alkyl; R3 and R5 is lower alkyl, phenyl or phenyl-lower alkyl; and R4 is a five- or six-member nitrogen and/or sulfur or oxygen-containing ring system; are useful as antibacterial agents.

3-Heterothio derivatives of (carbamoylthioacetyl)cephalosporins

3-Heterothio(carbamoylthioacetyl)cephalosporin derivatives of the general formula EQU1 wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, tri(lower alkyl)silyl, a salt forming ion or the group EQU2 R1 is hydrogen, lower alkyl, phenyl, thienyl, or pyridyl; R2 is lower alkyl or phenyl-lower alkyl; R3 is a five or six membered nitrogen, sulfur and/or oxygen containing ring system; and R4 is lower alkyl, phenyl or phenyl-lower alkyl; are useful as antibacterial agents.

3-Heterothio derivatives of (α-thiocarbonylamino) cephalosporins

3-Heterothio(α-thiocarbonylamino)cephalosporin derivatives of the general formula STR1 wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl, a salt forming ion or the group STR2 R1 is hydrogen, lower alkyl, cyclo-lower alkyl, unsaturated cyclo-lower alkyl, phenyl, substituted phenyl or thienyl; R2 and R5 each is hydrogen or lower alkyl; R3 is a five or six membered nitrogen, sulfur and/or oxygen containing ring system; and R4 is lower alkyl, phenyl or phenyl-lower alkyl; are useful as antibacterial agents.