56737-24-7

Upstream product

• 26970-95-6 7β-(thiophen-2-acetamido)-3-<(2-methyl-1,3,4-thiadiazol-5-yl)thiomethyl>-ceph-3-em-4-carboxylic acid 
• 908093-98-1 diazodiphenylmethane 
• 153-61-7 cephalothin 

Downstream Products

• 37059-79-3 benzhydryl 7β-amino-3-<(5-methyl-1,3,4-thiadiazol-2-yl)thiomethyl>-3-cephem-4-carboxylate 
• 120155-18-2 (6R,7R)-3-(5-Methyl-[1,3,4]thiadiazole-2-sulfonylmethyl)-5,8-dioxo-7-(2-thiophen-2-yl-acetylamino)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 120155-19-3 (6R,7R)-3-(5-Methyl-[1,3,4]thiadiazole-2-sulfonylmethyl)-5,5,8-trioxo-7-(2-thiophen-2-yl-acetylamino)-5λ⁶-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 120155-16-0 (6R,7R)-3-(5-Methyl-[1,3,4]thiadiazole-2-sulfinylmethyl)-5,8-dioxo-7-(2-thiophen-2-yl-acetylamino)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 120155-15-9 (6R,7R)-3-(5-Methyl-[1,3,4]thiadiazol-2-ylsulfanylmethyl)-5,8-dioxo-7-(2-thiophen-2-yl-acetylamino)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 

Relevant academic research and scientific papers

Synthesis and in vitro antimicrobial activity of 3-heteroarylsulphonylmethyl cephems: a new class of cephalosporins

A series of 3-heteroarylsulphonylmethyl and 3-heteroarylsulphenylmethyl cephems were prepared and tested for antimicrobial activities.In contrast to the adverse effect of oxidized ring sulphur of penams and cephems on antimicrobial activities, the oxidized side-chain sulphur of 3-mercaptoheteroaryl cephems retained Gram-negative and slightly decreased Gram-positive activity.The chemical nature of the moieties substituted at C-7 and C-3 positions also influenced the antibacterial activity and spectrum.Compounds with thienyl substitution at C-7 and sulphonylmethylthiazoles or sulphonylmethylthiadiazoles at C-3 exhibited good differentials in antibacterial activity versus their unoxidized counterparts. β-lactam / 3-heteroarylsulphonylcephem / oxidized cephem / antibacterial agent

OXIDATION STUDIES ON &β-LACTAM ANTIBIOTICS: IN-VITRO ANTIMICROBIAL ACTIVITY OF THE OXIDIZED PRODUCTS OF 3-HETEROARYLTHIOMETHYL-CEPH-3-EMS

Various products from the oxidation of 3-heteroarylthiomethyl-ceph-3-ems using m-chloroperbenzoic acid (m-CPBA) and hydrogen peroxide in acetic acid in varying stoichiometric ratios have been isolated, identified and their in vitro antimicrobial activity