370590-08-2Relevant academic research and scientific papers
Synthesis of a series of novel dihydroartemisinin derivatives containing a substituted chalcone with greater cytotoxic effects in leukemia cells
Yang, Xuelin,Wang, Wei,Tan, Jun,Song, Dandan,Li, Ming,Liu, Dan,Jing, Yongkui,Zhao, Linxiang
experimental part, p. 4385 - 4388 (2010/04/05)
Fifteen dihydroartemisinin derivatives containing a substituted chalcone linked by either ether or ester were synthesized and investigated for their cytotoxicity in human leukemia HL-60 and mouse lymphoma P388 cells. These derivatives have greater antiproliferative and cytotoxic effects in both cell lines than dihydroartemisinin. Dihydroartemisinin chalcones linked by ether are more cytotoxic than dihydroartemisinin chalcones linked by ester with apoptosis induction abilities.
Synthesis and bioefficacy evaluation of 2-[4-(3-arylprop-2-enoyl)phenoxy]-N-substituted acetamides and 2-[4-(5-aryl-4,5-dihydro-1H-pyrazol-3-yl)-phenoxy]acetic acid hydrazides as potential pesticides
Malik,Dahiya,Kumar,Sangwan,Mehta,Sangwa
, p. 682 - 687 (2007/10/03)
Base catalyzed condensation of 4-hydroxyacetophenone I with araldehydes 2-8 yields 3-aryl-1-(4-hydroxyphenyl)prop-2-eh-1-ones 9-15, The compounds 9-15 are alkylated with ethyl chloroacetate to furnish ethyl [4-(3-arylprop-2-enoyl)phenoxy]acetates 16-22. The esters 16-22 are subjected to nucleophilic displacement reactions with isopropylamine and morpholine to give the title compounds, 2-[4(-3-arylprop-2-enoyl)phenoxy]-N-isopropylacetamides 23-29 and 4-[{4-(3-arylprop-2-enoyl)phenoxy}acetyl]morpholine 30-36, respectively. The esters 16-22 are cyclized with excess of hydrazine hydrate in ethanol to give the title compounds, 2-[4-(5-aryl-4,5-dihydro-1H-pyrazol-3-yl)phenoxy]acetic acid hydrazides 37-43. All the compounds are tested for their toxicity against five phytopathogenic fungi, Rhizoctonia solani, Rhizoctonia bataticola, Sclerotinia sclerotiorum, Alternaria brassicae, and Fusarium solani, two saprophytic fungi Penicillium digitatum, and Aspergillus niger and one phytopathogenic bacterium Xanthomonas campestris pv. citrii. Some of the compounds inhibit the growth of S. sclerotiorum, A. niger and X. campestris pv. citrii at a concentration of 200 ppm.
