37063-35-7 Usage
Uses
Used in Pharmaceutical Industry:
ADENOSINE-2':3'-CYCLIC MONOPHOSPHATE, SODIUM SALT is used as an anticancer agent for its potential to target and inhibit cancer cell growth. It modulates cellular signaling pathways, leading to the suppression of tumor progression and the enhancement of chemo-sensitivity in resistant cases.
Used in Pharmaceutical Research:
As a pharmaceutical intermediate, ADENOSINE-2':3'-CYCLIC MONOPHOSPHATE, SODIUM SALT is utilized in the development and synthesis of novel therapeutic agents. Its unique chemical properties make it a valuable compound for exploring new drug candidates and advancing pharmaceutical research.
Used in Chemical Analysis:
ADENOSINE-2':3'-CYCLIC MONOPHOSPHATE, SODIUM SALT serves as an essential component in various analytical techniques, such as high-performance liquid chromatography (HPLC) and mass spectrometry. It is employed as a reference standard or internal control in the quantification and identification of related compounds in biological samples.
Biochem/physiol Actions
Adenosine 2′,3′-cyclic monophosphate (2′,3′-cAMP) is believed to serve as an extracellular source of adenosine. The release of extracellular 2′,3′-cAMP occurs in response to injury. 2′,3′-cAMP may be used to study the distribution and specificity of its degrading enzymes in the context of unique biological activities. 2′,3′-cAMP may also be used to study apoptosis induced at the level of mitochondrial permeability transition pores. 2′,3′-cAMP is converted into 2′-AMP and 3′-AMP which inhibit proliferation of preglomerular vascular smooth muscle cells and glomerular mesangial cells via A2B receptors.
Check Digit Verification of cas no
The CAS Registry Mumber 37063-35-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,7,0,6 and 3 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 37063-35:
(7*3)+(6*7)+(5*0)+(4*6)+(3*3)+(2*3)+(1*5)=107
107 % 10 = 7
So 37063-35-7 is a valid CAS Registry Number.
37063-35-7Relevant academic research and scientific papers
Phosphorylation, oligomerization and self-assembly in water under potential prebiotic conditions
Gibard, Clémentine,Bhowmik, Subhendu,Karki, Megha,Kim, Eun-Kyong,Krishnamurthy, Ramanarayanan
, p. 212 - 217 (2018/02/06)
Prebiotic phosphorylation of (pre)biological substrates under aqueous conditions is a critical step in the origins of life. Previous investigations have had limited success and/or require unique environments that are incompatible with subsequent generation of the corresponding oligomers or higher-order structures. Here, we demonstrate that diamidophosphate (DAP) - a plausible prebiotic agent produced from trimetaphosphate - efficiently (amido)phosphorylates a wide variety of (pre)biological building blocks (nucleosides/tides, amino acids and lipid precursors) under aqueous (solution/paste) conditions, without the need for a condensing agent. Significantly, higher-order structures (oligonucleotides, peptides and liposomes) are formed under the same phosphorylation reaction conditions. This plausible prebiotic phosphorylation process under similar reaction conditions could enable the systems chemistry of the three classes of (pre)biologically relevant molecules and their oligomers, in a single-pot aqueous environment.
RETRACTED ARTICLE: First prebiotic generation of a ribonucleotide from adenine, d-ribose and trimetaphosphate
Baccolini, Graziano,Boga, Carla,Micheletti, Gabriele
supporting information; experimental part, p. 3640 - 3642 (2011/05/04)
Adenosine monophosphate isomers are obtained by self-assembling of adenine, d-ribose and trimetaphosphate in aqueous solution in good yields. This generation of a ribonucleotide from its three molecular components occurs in a one-pot reaction at room temperature for about 30-40 days and with high chemio-, regio-, and stereo-selectivity. Similar results are obtained with guanine. A mechanism is also proposed.
