370874-64-9Relevant academic research and scientific papers
Synthesis and cyclooxygenase-2 inhibiting property of 1,5-diarylpyrazoles with substituted benzenesulfonamide moiety as pharmacophore: Preparation of sodium salt for injectable formulation
Pal, Manojit,Madan, Manjula,Padakanti, Srinivas,Pattabiraman, Vijaya R.,Kalleda, Srinivas,Vanguri, Akhila,Mullangi, Ramesh,Mamidi, N. V. S. Rao,Casturi, Seshagiri R.,Malde, Alpeshkumar,Gopalakrishnan,Yeleswarapu, Koteswar R.
, p. 3975 - 3984 (2007/10/03)
A series of 1,5-diarylpyrazoles having a substituted benzenesulfonamide moiety as pharmacophore was synthesized and evaluated for cyclooxygenase (COX-1/COX-2) inhibitory activities. Through SAR and molecular modeling, it was found that fluorine substituti
2-Fluorobenzenesulfonyl compounds for the treatment of inflammation
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, (2008/06/13)
Methods of treating cyclooxygenase-2 mediated disorders comprising administering to a subject a therapeutically effective amount of one or more 2-fluorobenzenesulfonyl compounds corresponding to Formula I: wherein A, R1, R2, and R3 are as described in the specification, and novel 2 fluorobenzenesulfonyl compounds within Formula I.
