13656-60-5

Usage

Uses

Used in Pharmaceutical Industry:
2,4-DIFLUOROBENZENESULFONAMIDE is used as a building block in the synthesis of pharmaceuticals for its potential anti-inflammatory and analgesic properties. It serves as a key component in the development of new drugs that could offer relief from inflammation and pain.
Used in Agrochemical Industry:
In the agrochemical sector, 2,4-DIFLUOROBENZENESULFONAMIDE is utilized as a precursor in the production of various agrochemicals, contributing to the development of more effective and targeted pest control solutions.
Used in Organic Light-Emitting Diodes (OLEDs) Industry:
2,4-DIFLUOROBENZENESULFONAMIDE is employed as an electron acceptor material in the fabrication of OLEDs, enhancing their performance and efficiency in display and lighting technologies.
Used in Chemical Research and Development:
2,4-DIFLUOROBENZENESULFONAMIDE's wide-ranging applications and potential make 2,4-DIFLUOROBENZENESULFONAMIDE an important subject of study in chemical research and development, where it is explored for new uses and improvements in existing technologies.

InChI:InChI=1/C6H5F2NO2S/c7-4-1-2-6(5(8)3-4)12(9,10)11/h1-3H,(H2,9,10,11)

Upstream product

• 1336-21-6 ammonium hydroxide 
• 13918-92-8 2,4-difluorobenzene-1-sulfonyl chloride 
• 1996-44-7 2,4-difluorothiophenol 
• 367-25-9 2,4-difluorophenylamine 
• 3782-65-8 2,4-Difluorobenzene sulfonyl fluoride 
• 26120-88-7 2,4-dichlorobenzenesulfonyl fluoride 
• 372-18-9 1,3-Difluorobenzene 

Downstream Products

• 1057257-37-0 C₂₈H₂₀F₂N₂O₄S 
• 1209468-30-3 C₁₁H₁₅FN₂O₂S 
• 1209468-39-2 C₁₁H₁₅FN₂O₂S 
• 1228944-63-5 4-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)-2-fluorobenzenesulfonamide 
• 1130322-33-6 C₂₆H₁₈ClF₂N₅O₄S 
• 1204572-62-2 2-cyclopropylamino-4-fluorobenzenesulphonamide 
• 370874-64-9 2-Fluoro-4-Hydrazino-Benzenesulfonamide 

Relevant academic research and scientific papers

THIAZOLIDINONE COMPOUNDS AND USE THEREOF

A pharmaceutical composition containing a compound of Formula (I) for treating an opioid receptor-associated condition. Also disclosed is a method for treating an opioid receptor-associated condition using such a compound. Further disclosed are two sets of thiazolidinone compounds of formula (I): (i) compounds each having an enantiomeric excess greater than 90% and (ii) compounds each being substituted with deuterium.

A general iodine-mediated synthesis of primary sulfonamides from thiols and aqueous ammonia

A general and efficient methodology for preparing primary sulfonamides has been developed. In the presence of iodine as the catalyst and TBHP (70% in water) as the oxidant, a wide range of primary sulfonamides were prepared from the corresponding thiols and aqueous ammonia in moderate to good yields.

Thermodynamic characterization of new positive allosteric modulators binding to the glutamate receptor A2 ligand-binding domain: Combining experimental and computational methods unravels differences in driving forces

Positive allosteric modulation of the ionotropic glutamate receptor GluA2 presents a potential treatment of cognitive disorders, for example, Alzheimer's disease. In the present study, we describe the synthesis, pharmacology, and thermodynamic studies of a series of monofluoro-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides. Measurements of ligand binding by isothermal titration calorimetry (ITC) showed similar binding affinities for the modulator series at the GluA2 LBD but differences in the thermodynamic driving forces. Binding of 5c (7-F) and 6 (no-F) is enthalpy driven, and 5a (5-F) and 5b (6-F) are entropy driven. For 5d (8-F), both quantities were equal in size. Thermodynamic integration (TI) and one-step perturbation (OSP) were used to calculate the relative binding affinity of the modulators. The OSP calculations had a higher predictive power than those from TI, and combined with the shorter total simulation time, we found the OSP method to be more effective for this setup. Furthermore, from the molecular dynamics simulations, we extracted the enthalpies and entropies, and along with the ITC data, this suggested that the differences in binding free energies are largely explained by the direct ligand-surrounding enthalpies. Furthermore, we used the OSP setup to predict binding affinities for a series of polysubstituted fluorine compounds and monosubstituted methyl compounds and used these predictions to characterize the modulator binding pocket for this scaffold of positive allosteric modulators.

Cycloalkylated benzothiadiazines, a process for their preparation and pharmaceutical compostions containing them

Compounds of formula (I): wherein: RCy represents an unsubstituted or substituted cycloalkyl group or cycloalkylalkyl group,R1, R2, R3 and R4, which may be the same or different, each represent a hydrogen or halogen atom or a nitro group; a cyano group; a hydroxy group; an alkoxy group; an alkyl group; an unsubstituted or substituted amino group; a carboxy group; an alkoxycarbonyl group; an aryloxycarbonyl group; an unsubstituted or substituted aminocarbonyl group. Medicinal products containing the same which are useful in treating or preventing conditions treatable by an AMPA receptor modulator.

Synthesis and cyclooxygenase-2 inhibiting property of 1,5-diarylpyrazoles with substituted benzenesulfonamide moiety as pharmacophore: Preparation of sodium salt for injectable formulation

A series of 1,5-diarylpyrazoles having a substituted benzenesulfonamide moiety as pharmacophore was synthesized and evaluated for cyclooxygenase (COX-1/COX-2) inhibitory activities. Through SAR and molecular modeling, it was found that fluorine substituti

2-Fluorobenzenesulfonyl compounds for the treatment of inflammation

Methods of treating cyclooxygenase-2 mediated disorders comprising administering to a subject a therapeutically effective amount of one or more 2-fluorobenzenesulfonyl compounds corresponding to Formula I: wherein A, R1, R2, and R3 are as described in the specification, and novel 2 fluorobenzenesulfonyl compounds within Formula I.