370880-07-2

Upstream product

• 370880-03-8 (3aR,6aR)-1-[(1R)-1-phenylethyl]-3,3a,4,5,6,6a-hexahydro-2H-pyrrolo[3,2-c]pyrrole 
• 407-25-0 trifluoroacetic anhydride 
• 370880-12-9 (3aS,6aS)-1-[(1R)-1-phenylethyl]-3,3a,4,5,6,6a-hexahydro-2H-pyrrolo[3,4-b]pyrrole 

Downstream Products

• 1350553-88-6 tert-butyl (R)-1-(2,4,5-trifluorophenyl)-4-((3aS,6aS)-hexahydro-5-(cyclopropylsulfuryl)-pyrrolo[3,4-b]pyrrol-1(2H)-yl)-4-oxybutan-2-ylcarbamate 
• 1350552-81-6 (R)-3-amino-1-((3aS,6aS)-5-(2-fluoro-2-methylpropionyl)-hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 
• 1350553-77-3 tert-butyl (R)-1-(2,4,5-trifluorophenyl)-4-((3aS,6aS)-hexahydro5-methoxyformylpyrrolo[3,4-b]pyrrol-1(2H)-yl)-4-oxybutan-2-ylcarbamate 
• 1350553-78-4 tert-butyl (R)-1-(2,4,5-trifluorophenyl)-4-((3aS,6aS)-hexahydro-5-(N,N-dimethylaminoformyl)-pyrrolo[3,4-b]pyrrol-1(2H)-yl)-4-oxybutan-2-ylcarbamate 
• 1350553-80-8 tert-butyl (R)-1-(2,4,5-trifluorophenyl)-4-((3aS,6aS)-hexahydro-5-(methylaminoformyl)-pyrrolo[3,4-b]pyrrol-1(2H)-yl)-4-oxybutan-2-ylcarbamate 
• 1350553-81-9 tert-butyl (R)-1-(2,4,5-trifluorophenyl)-4-((3aS,6aS)-hexahydro-5-(aminoformyl)-pyrrolo[3,4-b]pyrrol-1(2H)-yl)-4-oxybutan-2-ylcarbamate 
• 1350553-84-2 tert-butyl (R)-1-(2,4,5-trifluorophenyl)-4-((3aS,6aS)-hexahydro-5-(2-fluoro-2-methylpropionyl)-pyrrolo[3,4-b]pyrrol-1(2H)-yl)-4-oxybutan-2-ylcarbamate 
• 1350552-85-0 (R)-3-amino-1-((3aS,6aS)-5-(2-fluoro-2-methylpropionyl)-hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one hydrochloride 
• 1350552-89-4 (R)-3-amino-1-((3aS,6aS)-5-(2-fluoro-2-methylpropionyl)-hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl)-4-(2,4,5-trifluorophenyl)butane-1-one methanesulfonate 
• 1350553-85-3 tert-butyl (R)-1-(2,4,5-trifluorophenyl)-4-((3aS,6aS)-hexahydro-5-(cyclopropylformyl)-pyrrolo[3,4-b]pyrrol-1(2H)-yl)-4-oxybutan-2-ylcarbamate 
• 370880-08-3 tert-butyl (3aR,6aR)-5-(trifluoroacetyl)hexahydropyrrolo[3,4-b]pyrrole-1 (2H)-carboxylate 

Relevant academic research and scientific papers

HEXAHYDROPYRROLO[3,4-b]PYRROLE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF

Hexahydropyrrolo[3,4-b]pyrrole derivatives, preparation methods and pharmaceutical uses thereof are provided. Specifically, dipeptidyl peptidase IV inhibitors presented by following formula (I) are provided. Such compounds can be used for treating or preventing the diseases associated with dipeptidyl peptidase IV, such as diabetes, obesity and hyperlipemia. The compounds presented by formula (I) and pharmaceutically acceptable salts thereof, a method for preparing a pharmaceutical composition thereof and their uses in the manufacture of medicaments for treating or preventing the disease associated with dipeptidyl peptidase IV are provided.

Substituted diazabicycloalkane derivatives

Compounds of formula (I) [in-line-formulae]Z-Ar1—Ar2??(I) [/in-line-formulae] wherein Z is a diazabicyclic amine, Ar1 is a 5- or 6-membered aromatic ring, and Ar2 is selected from the group consisting of an unsubstituted or substituted 5- or 6-membered heteroaryl ring; unsubstituted or substituted bicyclic heteroaryl ring; 3,4-(methylenedioxy)phenyl; carbazolyl; tetrahydrocarbazolyl; naphthyl; and phenyl; wherein the phenyl is substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.