37102-48-0Relevant articles and documents
Modular Access to Eight-Membered N-Heterocycles by Directed Carbonylative C?C Bond Activation of Aminocyclopropanes
Boyd, Olivia,Wang, Gang-Wei,Sokolova, Olga O.,Calow, Adam D. J.,Bertrand, Sophie M.,Bower, John F.
supporting information, p. 18844 - 18848 (2019/11/28)
Aminocyclopropanes equipped with pendant nucleophiles undergo carbonylative heterocyclization triggered by C?C bond activation to generate eight-membered N-heterocycles. In these processes, intramolecular “capture” of a rhodacyclopentanone intermediate by an aryl or N-based nucleophile is followed by C?C or C?N bond-forming “collapse” to the targets. These studies demonstrate how the combination of cyclopropane strain release and the templating effect of catalytically generated metallacycles can be harnessed to enable otherwise challenging medium ring closures.
HETEROARYL DERIVATIVES AS SEPIAPTERIN REDUCTASE INHIBITORS
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Paragraph 00916-00918, (2017/05/31)
Inhibitors of sepiapterin reductase of formula (I) or (I'), wherein the substituents are defined as in the claims, and uses of sepiapterin reductase inhibitors in analgesia, treatment of acute and chronic pain, anti-inflammation, and immune cell regulation are disclosed.
PYRROLE AMIDE INHIBITORS
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Paragraph 0604, (2014/09/30)
The present invention provides for compounds of formula (I) wherein R1, R2, R3, and R10 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).
