3168-85-2

Usage

Uses

Used in Organic Synthesis:
2-METHYL-1H-PYRROLE-3-CARBOXYLIC ACID METHYL ESTER is used as a key intermediate in the synthesis of complex organic molecules, facilitating the construction of diverse chemical structures for various applications.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2-METHYL-1H-PYRROLE-3-CARBOXYLIC ACID METHYL ESTER is used as a building block for the development of new drugs, particularly those with potential anti-inflammatory and anti-cancer properties, due to its inherent biological activity.
Used in Material Science:
2-METHYL-1H-PYRROLE-3-CARBOXYLIC ACID METHYL ESTER is utilized in the research and development of new materials, where its chemical properties may contribute to the creation of innovative substances with unique characteristics.
Used in Chemical Process Development:
2-METHYL-1H-PYRROLE-3-CARBOXYLIC ACID METHYL ESTER is also used in the development of new chemical processes, where its reactivity and functional groups can be leveraged to improve or create novel synthetic pathways.

InChI:InChI=1/C7H9NO2/c1-5-6(3-4-8-5)7(9)10-2/h3-4,8H,1-2H3

Upstream product

• 186581-53-3 diazomethane 
• 37102-48-0 2-methyl-1H-pyrrole-3-carboxylic acid 
• 87281-49-0 N-benzyl-3-carbomethoxy-2-methylpyrrole 
• 157-22-2 diazirine 
• 292638-85-8 acrylic acid methyl ester 
• 75-05-8 acetonitrile 
• 922-67-8 propynoic acid methyl ester 
• 98587-57-6 methyl nitrile ylide 
• 103852-58-0 <1-(phenylthio)ethylidene>-1-(trimethylsilyl)methylamine 
• 879214-69-4 (Z)-3-(2,2-Diethoxy-ethylamino)-but-2-enoic acid methyl ester 
• 1135793-18-8 methyl 3-[(2,2-diethoxyethyl)amino]but-2-enoate 

Relevant academic research and scientific papers

Synthesis of 3-Acylpyrroles, 3-(Alkoxycarbonyl)pyrroles, 1,5,6,7-Tetrahydro-4H-indol-4-ones and 3-Benzoylpyridines Based on Staudinger-Aza-Wittig Reactions of 1,3-Dicarbonyl Compounds with 2- and 3-Azido-1,1-dialkoxy- alkanes

The Staudinger-aza-Wittig reaction of 1,3-dicarbonyl compounds with 2-azido-1,1-diethoxyethane and subsequent cy- clization allowed an efficient synthesis of a variety of pyrroles, 1,5,6,7-tetrahydro-4H-indol-4-ones, and of a pyridine. Georg Thieme Verlag

Synthesis of functionalized pyrroles and 6,7-dihydro-1H-indol-4(5H)-ones by reaction of 1,3-dicarbonyl compounds with 2-azido-1,1-diethoxyethane

The condensation of 1,3-dicarbonyl compounds with 2-azido-1,1- diethoxyethane and subsequent cyclization allowed an efficient synthesis of a variety of pyrroles and 6,7-dihydro-1H-indol-4(5H)-ones.

Synthesis of 2-alkylidenepyrrolidines, pyrroles, and indoles by condensation of silyl enol ethers and 1,3-bis-silyl enol ethers with 1-azido-2,2-dimethoxyethane and subsequent reductive cyclization

The condensation of 1,3-bis-silyl enol ethers with 1-azido-2,2- dimethoxyethane and subsequent reductive cyclization allowed an efficient regio- and diastereoselective synthesis of a variety of 2-alkylidene-4- methoxypyrrolidines. The thermal elimination of methanol resulted in the formation of functionalized pyrroles. Similarly, 2,3,3a,4,5,6-hexahydro-2,3- benzopyrroles were prepared and transformed into 4,5,6,7-tetrahydro-2,3- benzopyrroles. In contrast, treatment of 2-alkylidenepyrrolidines with trifluoroacetic acid resulted in formation of indoles by [4 + 2] cycloaddition and subsequent extrusion of a nitrogen atom.

Carbene and Silicon Routes toward a Simple Nitrile Ylide. Spectroscopic, Kinetic, and Chemical Characterization

The generation and characterization of methyl nitrile ylide photochemically by addition of singlet methylene to acetonitrile and chemically from silylthioimidate and subsequent dipolar cycloaddition are carried out.