37110-39-7Relevant academic research and scientific papers
Substituted silyl alkylene amines
-
, (2008/06/13)
This invention relates to substituted silyl alkylene amines, to the intermediates and processes useful for their preparation, to their pharmacological use as MAO-B inhibitors and to their end-use application in the treatment of Parkinson's Disease and senile dementia of Alzheimer's type.
BASE CLEAVAGE OF THE BENZYL-SILICON BOND IN PhCH2SiMe2(CH2)nOH (n = 2 or 3) COMPOUNDS
Eaborn, Colin,Mahmoud, Foad M.S.
, p. 13 - 16 (2007/10/02)
The compounds PhCH2SiMe2(CH2)nOH with n = 2 or 3 are cleaved 0.75 and 95-135 times, respectively, as readily as PhCH2SiMe3 by NaOMe/MeOH at 50 deg C.The high reactivity of the compound with n = 3 may arise from intramolecular attack of the alkoxide centre
