5356-99-0Relevant articles and documents
Amphipathic coating for modulating cellular adhesion composition and methods
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, (2008/06/13)
The present invention provides an anti-thrombogenic and cellular-adhesion coating composition for blood-contacting surfaces. The coating comprises a covalent complex of from 1 to 30 hydrophobic silyl moieties of Formula I: wherein R1is an Csub
Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents
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, (2008/06/13)
This invention relates to compounds of the formula STR1 wherein R1 and R6 are each independently C1 -C6 alkyl; R2, R3 and R4 are each independently hydrogen or C1 -C6 alkyl; R is hydrogen or --C(O)--(CH2)m --Q wherein Q is hydrogen or --COOH and m is an integer 1, 2, 3 or 4; Z is a thio, oxy or methylene group; A is a C1 -C4 alkylene group; R5 and R7 are each independently a C1 -C6 alkyl or --(CH2)n --(Ar) wherein n is an integer 0, 1, 2 or 3; and Ar is phenyl or naphthyl unsubstituted or substituted with one to three substituents selected from the group consisting of hydroxy, methoxy, ethoxy, halogen, trifluoromethyl, C1 -C6 alkyl, or --NR8 R9, wherein R8 and R9 are each independently hydrogen or C1 -C6 alkyl; with the proviso that when R2 and at least one of R5 or R7 is C1 -C6 alkyl, and Ar is not substituted with trifluoromethyl or --NR8 R9, then R is --C(O)--(CH2)m --Q; or a pharmaceutically acceptable salt thereof; useful for the treatment of atherosclerosis and chronic inflammatory disorders; for inhibiting cytokine-induced expression of VCAM-1 and/or ICAM-1; for inhibiting the peroxidation of LDL lipid; for lowering plasma cholesterol; and as antioxidant chemical additives useful for preventing oxidative deterioration in organic materials.
Benzylic lithium compounds: The missing link in carbon-lithium covalency. Dynamics of ion reorientation, rotation around the ring-benzyl bond, and bimolecular C-Li exchange
Fraenkel, Gideon,Martin, Kevin V.
, p. 10336 - 10344 (2007/10/02)
Benzyllithium compounds, hitherto assumed from NMR data to consist of ion pairs, have been found to exhibit spin coupling between 13C and directly bound 6Li under conditions wherein bimolecular carbon - lithium bond exchange is too slow to average the coupling constants. These conditions involved the use of species in which lithium is internally solvated or of dilute solutions (0.005 M) of benzyllithium-13C-6Li (enriched at Cα) at low temperature. The low values of 1J(13C-6Li), 3-4 Hz, imply a small detectable degree of C-Li covalence with the arrangement around Cα distorted from coplanarity. The C-Li bonds in benzyllithium are concluded to lie in a continuum of C-Li covalency between the many monomeric species in which 1J(13C-6Li) is 16 ± 1 Hz and separated ion pairs. NMR line shape analysis of data for internally solvated benzyllithium 2b provides quantitative insight into the dynamics of intramolecular reorientation of coordinated lithium with respect to the benzyl plane, rotation around the ring-Cα bond, and bimolecular carbon-lithium bond exchange, listed in order of widely different increasing rates, the activation parameters being ΔH? (kcal/mol) and ΔS? (eu) in the same order: 14 and 6.6; 6.4 and -14; 10.8 and -21.
