371124-27-5Relevant articles and documents
Design, synthesis, characterization, and antimicrobial activity of biginelli products of indandione
Dabholkar, Vijay V.,Patil, Sunil R.,Pandey, Rajesh V.
, p. 929 - 932 (2012)
A simple and efficient method has been developed for the synthesis of 4-(substituted phenyl)-3,4-dihydro-1H-indeno [1,2-d] pyrimidine-2,5-dione (5) and 4-(substituted phenyl)-2-thioxo-1,2,3,4-tetrahydroindeno [1,2-d] pyrimidine-5-one (6), by a one-pot three component cyclocondensation reaction of 1,3 dicarbonyl compound (Indandione) (1), aromatic aldehyde (2), and urea/thiourea (3/4) using catalytic amount of conc. HCl in refluxing ethanol. Representative samples were screened for their antimicrobial activity against gram-negative bacteria, E coli and Paeruginosa and gram-positive bacteria, S aureus, and C diphtheriae using disc diffusion method. The structures of the products were confirmed by IR, 1H, 13C NMR, and elemental analysis.
An efficient and modified biginelli-type synthesis of 3,4-dihydro-1H-indeno[1,2-d]pyrimidine-2,5-dione using phosphorous pentoxide
Warekar, Poojali P.,Kolekar, Govind B.,Deshmukh, Madhukar B.,Anbhule, Prashant V.
supporting information, p. 3594 - 3601 (2015/08/11)
A simple, clean and convenient one-pot method has been developed for the synthesis of 4-phenyl-3,4-dihydro-1H-indeno[1,2-d]pyrimidine-2,5-dione and 4-phenyl-2-thioxo-1,2,3,4-tetrahydro-5H-indeno[1,2-d]pyrimidine-5-one by multicomponent condensation of 1,3-indanedione, aromatic aldehydes and urea/thiourea using phosphorus pentoxide in ethanol under reflux conditions. The simple workup procedure and moderate to good yields within short time are some important features of this protocol. The synthesized compounds have been interpreted on the basis of their spectroscopic data.
