371150-01-5Relevant articles and documents
Chlorocyclopropane macrolides from the marine sponge Phorbas sp. assignment of the configurations of phorbasides A and B by quantitative CD
Skepper, Colin K.,MacMillan, John B.,Zhou, Guang-Xiong,Masuno, Makoto N.,Molinski, Tadeusz F.
, p. 4150 - 4151 (2008/02/04)
Two new chlorocyclopropane macrolides, phorbasides A and B, have been characterized from the sponge Phorbas sp. that previously yielded phorboxazoles A and B. We describe the assignment of the absolute configuration of the trans-chlorocyclopropane ring th
Process for producing optically active propargyl alcohols
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, (2008/06/13)
A process for producing an optically active propargyl alcohol represented by the following formula (4): wherein R1 is an alkyl group, a cycloalkyl group, an alkenyl group, a cycloalkenyl group, an alklnyl group, an alkylsilyl group, an aromatic hydrocarbon group, a C2-C10 heterocyclic group having 1-3 heteroatoms or a C1-C10 alkyl group having 1-3 heteroatoms, and R2 is an alkyl group, a cycloalkyl group, an alkenyl group, a cycloalkenyl group, an alkynyl group, an alkylsilyl group, an aromatic hydrocarbon group, a C2-C10 heterocyclic group having 1-3 heteroatoms or a C1-C10 alkyl group having 1-3 heteroatoms, which comprises allowing an aldehyde compound represented by the following formula (1): R1—CHO??(1) to react with an alkyne compound represented by the following formula (2): HC≡C—R2??(2) in the presence of an optically active aminoalcohol and a tertiary amine and a zinc halogenated lower alkane sulfonate in an amount of less than equivalent molar base on the aldehyde compound of formula (1); without solvent or with a solvent in an amount of 10-fold by weight or less based on the aldehyde compound of formula (1); and according to the process, high volumetrically efficiency and atomic economy can be attained, the objective optically active propargyl alcohol can be obtained in a high yield and a high enatioselectivity.
