128241-52-1

Basic information

• Product Name: (R)-1-cyclohexylprop-2-yn-1-ol
• Synonyms: (R)-1-cyclohexylprop-2-yn-1-ol
• CAS NO: 128241-52-1
• Molecular Weight: 138.21
• Mol File: 128241-52-1.mol
• Article Data: 51

Chemical Properties

• CAS DataBase Reference: (R)-1-cyclohexylprop-2-yn-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-cyclohexylprop-2-yn-1-ol(128241-52-1)
• EPA Substance Registry System: (R)-1-cyclohexylprop-2-yn-1-ol(128241-52-1)

Safety Data

• Hazardous Substances Data: 128241-52-1(Hazardous Substances Data)

Upstream product

• 2043-61-0 cyclohexanecarbaldehyde 
• 1066-54-2 trimethylsilylacetylene 
• 371150-01-5 (R)-1-cyclohexyl-3-(triethylsilyl)prop-2-yn-1-ol 
• 108-05-4 vinyl acetate 
• 97563-45-6 1-cyclohexylprop-2-yn-1-ol 
• 133216-88-3 (R)-1-cyclohexyl-3-(trimethylsilyl)prop-2-yn-1-ol 
• 1440569-82-3 3-(tert-butyldimethylsilyl)-1-cyclohexyl-2-propyn-1-one 
• 1440569-84-5 C₁₅H₂₈OSi 
• 133216-88-3 (+/-)-1-cyclohexyl-3-(trimethylsilyl)-2-propynol 
• 74-86-2 acetylene 
• 7560-69-2 1-cyclohexyl-2-propyn-1-one 
• 82510-26-7 3-cyclohexyl-3R-hydroxy-1-iodoprop-1E-ene 
• 65032-27-1 ethynylmagnesium chloride 
• 75-20-7 calcium carbide 

Downstream Products

• 115534-02-6 (R)-5-Cyclohexyl-2-methyl-penta-3,4-dienoic acid ethyl ester 
• 936638-45-8 (R)-1-cyclohexylprop-2-yn-1-yl acetate 
• 1231753-24-4 2-cyclohexyloxetan-3-one 
• 1319722-61-6 [1-({[(1-cyclohexylprop-2-ynyl)oxy]dithio}oxy)prop-2-ynyl]cyclohexane 
• 37868-74-9 3-cyclohexyl-2-propenal 
• 172376-40-8 (S)-1-cyclohexyl-1,3-propanediol 
• 42134-55-4 3-cyclohexyl-2-propen-1-ol 
• 108104-21-8 (S)-1-cyclohexyl-2-propyn-1-ol acetate 
• 53921-85-0 1-cyclohexyl-3-(N,N-dimethylamino)-1-propanone 
• 130708-23-5 1-cyclohexyl-3-phenylprop-2-yn-1-ol 

Relevant articles and documents

Highly enantioenriched propargylic alcohols by oxazaborolidine-mediated reduction of acetylenic ketones

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Sc(OTf)3-catalyzed [3 + 2]-cycloaddition of nitrones with ynones

An efficient approach to access functionalized (2,3-dihydroisoxazol-4-yl) ketones has been developed by reacting nitrones 4 with ynones 7 or terminal ynones 10 in a one-pot fashion. The reaction went through a formal Sc(OTf)3-catalyzed [3 + 2]-cycloaddition process to generate a number of functionalized (2,3-dihydroisoxazol-4-yl) ketones 11aa-11aw, 11ba-11la and 12aa-12ae in moderate to good yields. This journal is

The Synthesis of Chiral Allyl Carbamates via Merger of Photoredox and Nickel Catalysis

A mild, and versatile, organophotoredox/Ni-mediated protocol was developed for the direct preparation of diverse, enantioenriched allyl carbamates. The reported approach represents a significant departure from classical step-by-step synthesis of allyl carbamates. This dual photoredox/Ni based strategy offers unrivalled capacity for convergent unification of readily available alkyl halides and chiral carbamates derived from 1-bromo-alken-3-ols with high chemoselectivity and efficiency. The reported photoredox/Ni catalyzed cross-coupling reaction is not limited to carbamates, but also to other O-derivatives such as esters, ethers, acetals, carbonates or silyl ethers. To demonstrate the utility of the reported protocol, the resulting allyl carbamates were transformed into functionalized non-racemic allylamines through a sigmatropic rearrangement reaction in enantiospecific manner. This approach allowed for synthesis of enantiomeric allylamines by a simple control of the geometry of a double bond of allyl carbamates. (Figure presented.).