371249-76-2Relevant academic research and scientific papers
Novel inhibitors of IMPDH: A highly potent and selective quinolone-based series
Watterson, Scott H.,Carlsen, Marianne,Dhar, T. G. Murali,Shen, Zhongqi,Pitts, William J.,Guo, Junqing,Gu, Henry H.,Norris, Derek,Chorba, John,Chen, Ping,Cheney, Daniel,Witmer, Mark,Fleener, Catherine A.,Rouleau, Katherine,Townsend, Robert,Hollenbaugh, Diane L.,Iwanowicz, Edwin J.
, p. 543 - 546 (2007/10/03)
A series of novel quinolone-based small molecule inhibitors of inosine monophosphate dehydrogenase (IMPDH) was explored. The synthesis and the structure-activity relationships (SARs) derived from in vitro studies are described.
Heterocycles that are inhibitors of IMPDH enzyme
-
, (2008/06/13)
Compounds of the formula 1wherein X1 is C(O), —S(O)—, or —S(O)2—; X2 is CR3 or N; X3 is —NH—, —O—, or —S—; X4 is CR4 or N; X5 is CR5 or N; and X6 is CR6 or N are useful as inhibitors of IMPDH enzyme. Thus, these compounds can be used as therapeutic agents for IMPDH-associated disorders.
