569352-87-0Relevant academic research and scientific papers
2-Substituted 5-oxazolyl indole compounds useful as IMPDH inhibitors and pharmaceutical compositions comprising same
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, (2008/06/13)
Compounds having the formula (I), are effective as inhibitors of IMPDH enzyme, wherein R3 is alkyl, substituted alkyl, alkoxy, haloalkoxy, or halogen, preferably methoxy, ethoxy, or trifluoromethoxy; and R1, R2, R4/s
INDOLE COMPOUNDS USEFUL AS IMPDH INHIBITORS
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Page 39, (2010/02/04)
Compounds having the Formula (I), are effective as inhibitors of IMPDH enzyme, wherein R3 is alkyl, substituted alkyl, alkoxy, haloalkoxy, or halogen, preferably methoxy, ethoxy, or trifluoromethoxy; and R1, R2, R4, and R5 are as defined in the specificat
Novel indole-based inhibitors of IMPDH: Introduction of hydrogen bond acceptors at indole C-3
Watterson, Scott H.,Dhar, T.G. Murali,Ballentine, Shelley K.,Shen, Zhongqi,Barrish, Joel C.,Cheney, Daniel,Fleener, Catherine A.,Rouleau, Katherine A.,Townsend, Robert,Hollenbaugh, Diane L.,Iwanowicz, Edwin J.
, p. 1273 - 1276 (2007/10/03)
The development of a series of novel indole-based inhibitors of 5′-inosine monophosphate dehydrogenase (IMPDH) is described. Various hydrogen bond acceptors at C-3 of the indole were explored. The synthesis and the structure-activity relationships (SARs) derived from in vitro studies are outlined.
