371258-75-2

Upstream product

• 1517-82-4 (1R,2S,5R,SS)-(-)-menthyl p-toluenesulfinate 
• 22717-57-3 methyl 6-hydroxy-m-toluate 
• 1519-39-7 (R)-methyl p-tolyl sulfoxide 
• 1450-72-2 5-methyl-2-hydroxyacetophenone 
• 2258-42-6 formyl acetic anhydride 
• 371258-74-1 (R)-1-(2-hydroxy-5-methylphenyl)-2-(4-methylphenylsulfinyl)ethanone 

Relevant academic research and scientific papers

Conjugate addition to 3-arylsulfinylchromones as a synthetic route to homochiral 2-substituted chromanones: Scope and limitations

A route to homochiral 2-substituted chromanones via the diastereoselective conjugate addition of organocopper reagents to 3-(p-tolylsulfinyl)chromones has been improved and used to prepare 2,6-dimethylchromanone (S)-4 and LL-D253α methyl ether (S)-6. The attempted preparation of a 2-phenylchromanone (flavanone) using this strategy was unsuccessful due to the lability of the intermediate 2-phenyl-3-(p-tolylsulfinyl)chromanone, which underwent sulfoxide elimination at room temperature to give the corresponding 2-phenylchromone (flavone).