371258-91-2

Upstream product

• 118-93-4 o-hydroxyacetophenone 
• 824-94-2 p-methoxybenzyl chloride 
• 2746-25-0 p-Methoxybenzyl bromide 

Downstream Products

• 131137-81-0 1-<2-<(4-Methoxyphenyl)methoxy>phenyl>-2-<(4-methylphenyl)sulphinyl>ethanone 
• 573974-68-2 2'-(4-methoxybenzyloxy)acetophenone tosylhydrazone 
• 405239-74-9 tert-butyl 2-amino-4-{1-[(benzyloxy)carbonyl]-3-piperidinyl}-6-{2-[(4-methoxybenzyl)oxy]phenyl}nicotinate 
• 118-93-4 o-hydroxyacetophenone 
• 38276-97-0 rac-cis-2-(4-methoxyphenyl)-3-methyl-2,3-dihydrobenzofuran 
• 38276-96-9 (±)-trans-2-(4-methoxyphenyl)-3-methyl-2,3-dihydrobenzofuran 
• 726180-53-6 N-{1-[2-(4-methoxybenzyloxy)phenyl]-2-methoxymethoxyvinyl}acetamide 
• 726180-42-3 1-[2-(4-methoxybenzyloxy)phenyl]-2-methoxymethoxyethanone 
• 726180-32-1 2-hydroxy-1-[2-(4-methoxybenzyloxy)phenyl]ethanone 

Relevant academic research and scientific papers

Tetraalkylammonium-templated stereoselective Norrish-Yang cyclization

Tetrabutylammonium salts serve as templates for the Norrish-Yang cyclization of 2-benzyloxy-acylbenzenes to give trans-dihydrobenzofuranols in high stereoselectivities. The dual cation-π interactions between an ammonium with a benzene ring and a carbonyl group play a key role in changing the conformation of the substrate, which was supported by ab initio calculations.

A convenient approach for the deprotection and scavenging of the PMB group using POCl3

A convenient and high yielding approach for the deprotection and scavenging of the p-methoxybenzyl (PMB) group in PMB ethers and PMB esters was developed using POCl3 as the reagent. 4-Methoxybenzyl chloride, a starting material used for the preparation of PMB ethers and esters was regenerated in the deprotection step. This mild and selective procedure tolerates several acid sensitive functional groups. The Royal Society of Chemistry 2013.

Synthesis and structure-activity relationships of novel IKK-β inhibitors. Part 3: Orally active anti-inflammatory agents

A series of 2-amino-3-cyano-4-alkyl-6-(2-hydroxyphenyl)pyridine derivatives was synthesized and evaluated as IκB kinase β (IKK-β) inhibitors. Modification of a novel IKK-β inhibitor 1 (IKK-β IC 50=1500nM, Cell IC50=8000nM) at the 4-p

Ruthenium porphyrin catalyzed intramolecular carbenoid C-H insertion. Stereoselective synthesis of Cis-disubstituted oxygen and nitrogen heterocycles

(Matrix presented) A ruthenium porphyrin-catalyzed stereoselective intramolecular carbenoid C-H insertion is described. Using [Ru II(TTP)(CO)] as catalyst, aryl tosylhydrazones are converted to 2,3-dihydrobenzofurans, 2,3-dihydroindoles, and β-lactams in good yields and remarkable cis selectivity (up to 99%). Enantioselective synthesis of 2,3-dihydrobenzofurans is also achieved with [RuII(D 4-Por*)(CO)] as catalyst, and up to 96% ee is attained.

Conjugate addition to 3-arylsulfinylchromones as a synthetic route to homochiral 2-substituted chromanones: Scope and limitations

A route to homochiral 2-substituted chromanones via the diastereoselective conjugate addition of organocopper reagents to 3-(p-tolylsulfinyl)chromones has been improved and used to prepare 2,6-dimethylchromanone (S)-4 and LL-D253α methyl ether (S)-6. The attempted preparation of a 2-phenylchromanone (flavanone) using this strategy was unsuccessful due to the lability of the intermediate 2-phenyl-3-(p-tolylsulfinyl)chromanone, which underwent sulfoxide elimination at room temperature to give the corresponding 2-phenylchromone (flavone).