37128-50-0 Usage
General Description
The chemical (2-methyl-1H-indol-3-yl)(pyridin-3-yl)methanone, also known as MI-503, is a small molecule inhibitor that targets the activity of the transcriptional coactivators p300/CBP. It has been shown to have potential anticancer effects, particularly in the treatment of various types of solid tumors such as lung, breast, and colon cancer. MI-503 works by inhibiting the interaction between p300/CBP and the transcription factor MYC, which is known to be dysregulated in many cancer types. This inhibition ultimately leads to the suppression of MYC-dependent gene expression and the induction of tumor cell death. Furthermore, MI-503 has been found to have synergistic effects when combined with other anticancer agents, making it a promising candidate for future cancer therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 37128-50-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,7,1,2 and 8 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 37128-50:
(7*3)+(6*7)+(5*1)+(4*2)+(3*8)+(2*5)+(1*0)=110
110 % 10 = 0
So 37128-50-0 is a valid CAS Registry Number.
37128-50-0Relevant articles and documents
Elucidation of the conformational properties of 3-pyridinoyl indoles as intermediates of cannabimimetics
Araki, Koji,Tabata, Hidetsugu,Makino, Kosho,Ujiie, Ryohei,Sezaki, Kohei,Nakayama, Hiroshi,Oshitari, Tetsuta,Natsugari, Hideaki,Takahashi, Hideyo
, p. 1423 - 1435 (2019/12/23)
The conformations of 3-pyridinoyl indoles, which are intermediates of 5-fluoropentyl-3-pyridinoyl indole, were investigated using their X-ray crystal structures. All derivatives existed as s-trans conformers. A pseudo-planar conformation was observed in the 2'-yl isomer of 3-pyridinoyl indoles. On the other hand, twisted conformations were observed in 3-pyridinoyl 2-methylindoles. The conformations of these compounds in solution were also investigated using VT-NMR.
