37129-04-7

Upstream product

• 4266-03-9 N-Methyl-2-(phenylmethyl)pyrrolidine 
• 201230-82-2 carbon monoxide 
• 931-20-4 1-methylpiperidin-2-one 
• 100-39-0 benzyl bromide 
• 542-28-9 3,4,5,6-tetrahydro-2H-pyran-2-one 
• 68975-22-4 (R)-3-benzyltetrahydro-2H-pyran-2-one 
• 74-83-9 methyl bromide 
• 81976-72-9 3-phenylmethyl-2-piperidinone 

Relevant academic research and scientific papers

Enantioselective alkylation of lactams and lactones via lithium enolate formation using a chiral tetradentate lithium amide in the presence of lithium bromide

Enantioselective alkylation of lactams and lactones can be realized up to 98% ee by deprotonation with a chiral tetradentate lithium amide (4b) in the presence of lithium bromide, and subsequent alkylation with active alkylating agents in non-chelating solvents.

Synthesis of quaternary α-perfluoroalkyl lactams via electrophilic perfluoroalkylation

Efficient protocols enabling the rapid installation of trifluoromethyl, as well as further functionalized fluoroalkyl groups by an electrophilic perfluoroalkylation of lactam-derived ketene silyl amides (KSAs) using hypervalent iodine reagents 1 and 2 have been developed.

Anticonvulsant and anxiolytic lactam and thiolactam derivatives

This invention relates to lactam and thiolactam derivatives having useful anticonvulsant and anxiolytic activity, pharmaceutical compositions containing these compounds and therapeutic applications using such compositions.