37134-40-0 Usage
Uses
Used in Veterinary Medicine:
BicozaMycin benzoate, FR 2054 is used as a veterinary antibiotic for the treatment of bacterial infections in animals. Its selective activity against Gram-negative bacteria makes it a valuable addition to the arsenal of antibiotics used in veterinary medicine, particularly for infections that are resistant to other commonly used antibiotics.
Used in Pharmaceutical Research:
Due to its unique properties and activity against Gram-negative bacteria, BicozaMycin benzoate, FR 2054 may also be used as a starting point for pharmaceutical research and development. Scientists can explore its potential for the creation of new antibiotics or the modification of existing ones to combat antibiotic-resistant bacteria.
Biological Activity
bicyclomycin benzoate is a novel antibiotic produced by s. sapporonensi [1]. bicyclomycin shows an inhibitory effect on gram-negative bacteria, such as e. coli, klebsiella, shigella, salmonella, citrobacter, e. cloacae, and the pathogenic group of neisseria [2]. bicyclomycin benzoate is inactive against proteus, p. aeruginosa, and gram-positive bacteria [1,2].
in vitro
the mig of bicyclomycin for e.coli nihj jc-2 was 25-50 μg/ml. bicyclomycin (25-50 μg/ml) completely inhibited formation of visible colonies or turbidity of this organism on agar plates, in nutrient broth, and in heart infusion broth [2]. bicyclomycin inhibited atpase activity in the presence of poly(dc) and ribo(c)10. the approximate ic50 value for inhibition of transcription termination at rho-dependent sites was 5 μm. the inhibitory effect of bicyclomycin on rho-dependent transcripts was accompanied by the appearance of a new set of transcripts. in the presence of poly(dc), bicyclomycin reversibly inhibited the ribo(c)10-stimulated atpase activity. the extrapolated ki for bicyclomycin was 2.8 μm without ribo(c)10, which was increased to 26 μm in the presence of ribo(c)10 [3].
in vivo
bicyclomycin showed therapeutic activity for infections with several strains of e. coli which were resistant to the control antibiotics. the ed50 of bicyclomycin for infection with gp-resistant e.coli 312 was 3.05 (1.47-7.66) mg/mouse [2].
references
[1] miyoshi, t. ,miyairi, n.,aoki, h., et al. bicyclomycin, a new antibiotic. i. taxonomy, isolation and characterization. j.antibiot.(tokyo) 25(10), 569-575(1972).[2] nishida, m. ,mine, y.,matsubara, t., et al. bicyclomycin, a new antibiotic. iii. in vitro and in vivo antimicrobial activity. j.antibiot.(tokyo) 25(10), 582-593(1972).[3] magyar a, zhang x, kohn h, et al. the antibiotic bicyclomycin affects the secondary rna binding site of escherichia coli transcription termination factor rho[j]. journal of biological chemistry, 1996, 271(41): 25369-25374.
Check Digit Verification of cas no
The CAS Registry Mumber 37134-40-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,7,1,3 and 4 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 37134-40:
(7*3)+(6*7)+(5*1)+(4*3)+(3*4)+(2*4)+(1*0)=100
100 % 10 = 0
So 37134-40-0 is a valid CAS Registry Number.
