37136-96-2Relevant academic research and scientific papers
Synthesis and Investigation of S-Substituted 2-Mercaptobenzoimidazoles as Inhibitors of Hedgehog Signaling
Gr??le, Simone,Susanto, Steven,Sievers, Sonja,Tavsan, Emel,Nieger, Martin,Jung, Nicole,Br?se, Stefan
supporting information, p. 931 - 935 (2017/09/22)
Due to the arising resistance of common drugs targeting the Hedgehog signaling pathway, the identification of new compound classes with inhibitory effect is urgently needed. We were able to identify S-alkylated 2-mercaptobenzoimidazoles as a new compound
Synthesis and evaluation of anticonvulsant activity of N -(2,5-dimethylphenoxy)-and N-[(2,3,5-trimethylphenoxy)alkyl] aminoalkanols
Waszkielewicz, Anna Maria,Gunia-Krzyzak, Agnieszka,Ceg? A, Marek,Marona, Henryk
, p. 89 - 99 (2015/02/05)
AseriesofnewN-(2,5-dimethylphenoxy)-andN-(2,3,5-trimethylphenoxy)alkylaminoalkanols [I-XVII]wassynthesizedandevaluatedforanticonvulsantactivity.Pharmacologicaltestsincludedmaximal electroshock(MES)andsubcutaneouspentetrazoleseizurethreshold(scMet)assaysaswellasneurotoxicity (TOX)evaluationinmiceafterintraperitoneal(i.p.)administrationand/orinratsafteroral(p.o.)administration. ThemostactivecompoundwasR-2N-[(2,3,5-trimethylphenoxy)ethyl]aminobutan-1-ol,whichexhibited 100%activityinMESatthedoseof30mg/kgbodyweight(mice,i.p.)and75%activityinMESat30mg/kg b.w.(rats,p.o.)withoutneurotoxicityattheactive doses.
