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12β-Hydroxybufalin is a steroidal lactone derived from the venom of the Chinese toad (Bufo gargarizans) and is a potent cardiotonic agent. It exhibits strong positive inotropic and vasodilatory effects, making it a potential candidate for the treatment of heart failure. The chemical structure of 12β-Hydroxybufalin consists of a bufadienolide skeleton with a hydroxyl group at the 12β position, which contributes to its unique pharmacological properties. Research on 12β-Hydroxybufalin is ongoing to explore its therapeutic potential and optimize its safety profile for clinical use.

3714-45-2

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3714-45-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 3714-45-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,7,1 and 4 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 3714-45:
(6*3)+(5*7)+(4*1)+(3*4)+(2*4)+(1*5)=82
82 % 10 = 2
So 3714-45-2 is a valid CAS Registry Number.
InChI:InChI=1/C24H34O5/c1-22-9-7-16(25)11-15(22)4-5-18-19(22)12-20(26)23(2)17(8-10-24(18,23)28)14-3-6-21(27)29-13-14/h3,6,13,15-20,25-26,28H,4-5,7-12H2,1-2H3/t15-,16+,17-,18?,19?,20-,22+,23+,24+/m1/s1

3714-45-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-[(3S,5R,10S,12R,13S,14S,17R)-3,12,14-trihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pyran-2-one

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

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More Details:3714-45-2 SDS

3714-45-2Upstream product

3714-45-2Downstream Products

3714-45-2Relevant academic research and scientific papers

Microbial hydroxylation of bufalin by Cunninghamella blakesleana and Mucor spinosus

Ye, Min,Han, Jian,Tu, Guangzhong,An, Dongge,Guo, Dean

, p. 626 - 628 (2008/09/21)

The microbial transformation of a cytotoxic bufadienolide, bufalin (1), was carried out using two strains of filamentous fungi. Cunninghamella blakesleana catalyzed the specific 12α-hydroxylation of bufalin and produced 12α-hydroxybufalin (2) and 7β,12α-dihydroxybufalin (3) as the major metabolites, together with 7β-hydroxybufalin (4) and 12β-hydroxybufalin (5) in low yields. Two minor products were isolated from the culture broth of Mucor spinosus and were identified as 7β,15α- dihydroxybufalin (6) and 5β,7β-dihydroxybufalin (7), respectively. Metabolites 2, 3, 6, and 7 are new compounds, and their structures were fully characterized by NMR and MS spectroscopy.

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