3714-77-0

Upstream product

• 83-38-5 2,6-dichlorobenzaldehyde 

Downstream Products

• 2008-58-4 2,6-dichlorobenzamide 
• 6579-27-7 2,6-Dichloro-N-hydroxybenzenecarboximidoyl chloride 
• 1268246-55-4 2-chloro-4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]benzaldehyde 
• 278597-30-1 [3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazol-4-yl]methanol 
• 1020570-56-2 3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazole-4-carbaldehyde 
• 1020569-65-6 ethyl 5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazole-4-carboxylate 

Relevant academic research and scientific papers

HETEROCYCLIC FXR MODULATORS

The present technology is directed to compounds of formula (I), compositions, and methods related to modulation of FXR. In particular, the present compounds and compositions may be used to treat FXR-mediated disorders and conditions, including, e.g., liver disease, hyperlipidemia, hypercholesteremia, obesity, metabolic syndrome, cardiovascular disease, gastrointestinal disease, and atherosclerosis, and renal disease.

A facile steroselective synthesis of Z-aldoximes from benzaldehyde and hydroxlaminehydrochloride in dry media

The synthesis of Z-arylaldoximes has been carried out under microwave conditions using CdSO4 as catalyst. The yields obtained were in the range 84-88%.

Titanium oxide (TiO2) catalysed one-step Beckmann rearrangement of aldehydes and ketones in solvent free conditions

In the presence of titanium oxide (TiO2) and without any additional organic solvents, Beckmann rearrangement of several ketones and aldehydes was performed in good yield.

Selective synthesis of E and Z isomers of oximes

The highly stereoselective conversion of aldehydes and ketones to their corresponding oximes with hydroxylamin hydrochloride are catalyzed by CuSO4 and K2CO3. This method occurs under mild reaction conditions with high yields.

One-step Beckmann rearrangement from carbonyl compounds and hydroxylamine hydrochloride in Al2O3/CH3SO3H (AMA) as a new reagent

A facile and efficient synthetic procedure, for one-step Beckmann rearrangement of aldehydes and ketones with hydroxylamine hydrochloride and Al2O3/CH3SO3H (AMA) has been developed; cyclohexanone has been converted into ε-caprolactam in a quantitative yield.

Process for preparing sulphurous 2-chloro-3-(4,5-dihydroisoxazol-3-yl)-benzoic acids

Sulfur-containing 2-chloro-3-(4,5-dihydro-3-isoxazolyl)-benzoic acids of the formula I in which the substituents have the meanings given in the description are prepared as described.