371783-90-3 Usage
Uses
Used in Organic Synthesis:
(1R)-1-[4-benzyloxy-3-(2-tert-butyldimethylsilyloxyethyl)phenyl]-2-bromoethan-1-tert-butyldimethylsilyloxyethane is used as a synthetic intermediate for the modification or derivatization of other molecules. Its multiple functional groups and chiral center allow for versatile reactions and the creation of a wide range of chemical products.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (1R)-1-[4-benzyloxy-3-(2-tert-butyldimethylsilyloxyethyl)phenyl]-2-bromoethan-1-tert-butyldimethylsilyloxyethane is used as a precursor for the development of chiral molecules. The chiral nature of the compound is crucial for the synthesis of enantiomerically pure pharmaceuticals, which can have different biological activities and reduce the risk of side effects.
Used in Chiral Molecule Preparation:
(1R)-1-[4-benzyloxy-3-(2-tert-butyldimethylsilyloxyethyl)phenyl]-2-bromoethan-1-tert-butyldimethylsilyloxyethane is utilized in the preparation of chiral molecules, which are essential in various industries such as pharmaceuticals, agrochemicals, and fragrances. (1R)-1-[4-benzyloxy-3-(2-tert-butyldimethylsilyloxyethyl)phenyl]-2-bromoethan-1-tert-butyldimethylsilyloxyethane's unique stereochemistry can lead to the production of enantiomerically pure compounds with specific biological activities.
Check Digit Verification of cas no
The CAS Registry Mumber 371783-90-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,7,1,7,8 and 3 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 371783-90:
(8*3)+(7*7)+(6*1)+(5*7)+(4*8)+(3*3)+(2*9)+(1*0)=173
173 % 10 = 3
So 371783-90-3 is a valid CAS Registry Number.
371783-90-3Relevant academic research and scientific papers
The practical synthesis of a uterine relaxant, Bis( 2-{[(2S)-2-({(2R)-2-hydroxy-2-[4-hydroxy-3-(2-hydroxyethyl) -phenyl]ethyl}amino) -1,2,3,4-tetrahydronaphthalen-7-yl]oxy}-N,N-dimethylacetamide) sulfate (KUR-1246)
Yanagi, Takashi,Kikuchi, Ken,Takeuchi, Hideki,Ishikawa, Takehiro,Nishimura, Toshihiro,Yamamoto, Iwao
, p. 1018 - 1023 (2007/10/03)
The synthetic route for a uterine relaxant, bis(2-{[ (2S)-2-({(2R)-2-hydroxy-2-[4-hydroxy-3- (2-hydroxyethyl)-phenyl]ethyl}amino) -1,2,3,4-tetrahydronaphthalen-7-y1]oxy}-N,N-dimethylacetamide) sulfate (KUR-1246), was established by the coupling of optically active components, the bromohydrin 14 and the amine 24. We now describe the practical synthesis of these two optically active components. Bromohydrin 14 was obtained by the asymmetric borane reduction of the prochiral phenacyl bromide 13 using a catalyst prepared from aluminum triethoxide and a chiral amino alcohol. The other optically active component 24 was prepared from (S)-AMT.
