371784-91-7

Upstream product

• 76782-82-6 tert-Butyldimethyl(prop-2-ynyloxy)silane 
• 371784-90-6 tert-butyl-(5-iodo-2-methyl-pentyloxy)-diphenyl-silane 
• 371784-88-2 ((Z)-(S)-5-Benzyloxy-2-methyl-pent-3-enyloxy)-tert-butyl-diphenyl-silane 
• 371784-89-3 (S)-5-(tert-butyldiphenylsilyloxy)-4-methyl-pentanol 
• 371784-87-1 (Z)-(S)-5-Benzyloxy-2-methyl-pent-3-en-1-ol 

Downstream Products

• 371785-00-1 (3S,6R,7S,8S)-11-((1S,2R)-2-Benzyloxymethyl-cyclopropyl)-1,3,7-tris-(tert-butyl-dimethyl-silanyloxy)-4,4,6,8-tetramethyl-undecan-5-one 
• 371785-06-7 (3S,6R,7S,8S)-11-((1R,2R)-2-Benzyloxymethyl-cyclopropyl)-1,3,7-tris-(tert-butyl-dimethyl-silanyloxy)-4,4,6,8-tetramethyl-undecan-5-one 
• 371784-99-5 (3S,6R,7S,8S)-11-((1S,2R)-2-Benzyloxymethyl-cyclopropyl)-1,3-bis-(tert-butyl-dimethyl-silanyloxy)-7-hydroxy-4,4,6,8-tetramethyl-undecan-5-one 
• 371785-05-6 (3S,6R,7S,8S)-11-((1R,2R)-2-Benzyloxymethyl-cyclopropyl)-1,3-bis-(tert-butyl-dimethyl-silanyloxy)-7-hydroxy-4,4,6,8-tetramethyl-undecan-5-one 
• 371785-01-2 (3S,6R,7S,8S)-11-((1S,2R)-2-Benzyloxymethyl-cyclopropyl)-3,7-bis-(tert-butyl-dimethyl-silanyloxy)-4,4,6,8-tetramethyl-5-oxo-undecanoic acid methyl ester 
• 371785-07-8 (3S,6R,7S,8S)-11-((1R,2R)-2-Benzyloxymethyl-cyclopropyl)-3,7-bis-(tert-butyl-dimethyl-silanyloxy)-4,4,6,8-tetramethyl-5-oxo-undecanoic acid methyl ester 
• 371785-34-1 [(S)-5-((1S,2R)-2-Benzyloxymethyl-cyclopropyl)-2-methyl-pentyloxy]-tert-butyl-diphenyl-silane 
• 371784-95-1 (E)-(S)-8-(tert-Butyl-diphenyl-silanyloxy)-7-methyl-oct-2-en-1-ol 
• 371784-93-9 (Z)-(S)-8-(tert-Butyl-diphenyl-silanyloxy)-7-methyl-oct-2-en-1-ol 
• 371784-47-3 Acetic acid (S)-5-((1S,2R)-2-benzyloxymethyl-cyclopropyl)-2-methyl-pentyl ester 
• 329009-85-0 (S)-5-((1S,2R)-2-Benzyloxymethyl-cyclopropyl)-2-methyl-pentan-1-ol 
• 371784-85-9 (S)-5-((1R,2R)-2-Benzyloxymethyl-cyclopropyl)-2-methyl-pentan-1-ol 
• 371785-36-3 (S)-5-((1S,2R)-2-Benzyloxymethyl-cyclopropyl)-2-methyl-pentanal 
• 371784-92-8 8-(tert-butyl-diphenyl-silanyloxy)-7-methyl-oct-2-yn-1-ol 

Relevant academic research and scientific papers

Cyclopropyl and cyclobutyl epothilone analogs

The invention relates to cis- and trans-12, 13-cyclopropyl and 12,13-cyclobutyl epothilones of formula I to IV wherein Ar is a radical represented by the following structure: and the other radicals and symbols have the meanings as defined herein; to their

Chemical synthesis and biological evaluation of cis- and trans-12,13-cyclopropyl and 12,13-cyclobutyl epothilones and related pyridine side chain analogues

The design, chemical synthesis, and biological evaluation of a series of cyclopropyl and cyclobutyl epothilone analogues (3-12, Figure 1) are described. The synthetic strategies toward these epothilones involved a Nozaki - Hiyama - Kishi coupling to form