371784-89-3Relevant articles and documents
The first enantioselective synthesis of palinurin
Perez, Manuel,Perez, Daniel I.,Martinez, Ana,Castro, Ana,Gomez, Generosa,Fall, Yagamare
supporting information; experimental part, p. 3252 - 3254 (2009/12/01)
The first enantioselective synthesis of palinurin has been accomplished starting from commercially available furaldehyde and (R)-methyl-3-hydroxy-2- methylpropionate; the key steps of the synthesis include the use of a chiral pyrrolidine to create the chiral tetronic moiety, and Horner-Wadsworth-Emmons, Wittig and Wittig-Horner reactions to construct the alkene units.
Total synthesis of halipeptins: Isolation of halipeptin D and synthesis of oxazoline halipeptin analogues
Nicolaou,Schlawe, Daniel,Kim, David W.,Longbottom, Deborah A.,De Noronha, Rita G.,Lizos, Dimitrios E.,Manam, Rama Rao,Faulkner, D. John
, p. 6197 - 6211 (2007/10/03)
The isolation from the marine sponge Leiosella cf. arenifibrosa and structural elucidation of halipeptin D (5). a relative of the previously isolated halipeptins A-C (1-3), is described along with the total synthesis of a number of oxazoline analogues (7a
Chemical synthesis and biological evaluation of cis- and trans-12,13-cyclopropyl and 12,13-cyclobutyl epothilones and related pyridine side chain analogues
Nicolaou,Namoto,Ritzen,Ulven,Shoji,Li,D'Amico,Liotta,French,Wartmann,Altmann,Giannakakou
, p. 9313 - 9323 (2007/10/03)
The design, chemical synthesis, and biological evaluation of a series of cyclopropyl and cyclobutyl epothilone analogues (3-12, Figure 1) are described. The synthetic strategies toward these epothilones involved a Nozaki - Hiyama - Kishi coupling to form
