371784-89-3

Upstream product

• 888484-13-7 ethyl (S)-5-((tert-butyldiphenylsilyl)oxy)-4-methylpentanoate 
• 1036278-66-6 dimethyl (S)-4-(tert-butyldiphenylsilyloxy)-3-methylbutane-1,1-dicarboxylate 
• 371784-87-1 (Z)-(S)-5-Benzyloxy-2-methyl-pent-3-en-1-ol 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 95514-03-7 (R)-methyl 3-(tert-butyl(diphenyl)silyloxy)-2-methylpropanoate 
• 91751-24-5 (R)-3-[(tert-butyldiphenylsilyl)oxy]-2-methylpropanal 
• 371784-88-2 ((Z)-(S)-5-Benzyloxy-2-methyl-pent-3-enyloxy)-tert-butyl-diphenyl-silane 

Downstream Products

• 887706-56-1 (5-benzyloxy-2-methyl-pentyloxy)-tert-butyl-diphenyl-silane 
• 1289158-50-4 C₂₇H₃₈O₃Si 
• 371785-00-1 (3S,6R,7S,8S)-11-((1S,2R)-2-Benzyloxymethyl-cyclopropyl)-1,3,7-tris-(tert-butyl-dimethyl-silanyloxy)-4,4,6,8-tetramethyl-undecan-5-one 
• 371785-06-7 (3S,6R,7S,8S)-11-((1R,2R)-2-Benzyloxymethyl-cyclopropyl)-1,3,7-tris-(tert-butyl-dimethyl-silanyloxy)-4,4,6,8-tetramethyl-undecan-5-one 
• 371784-99-5 (3S,6R,7S,8S)-11-((1S,2R)-2-Benzyloxymethyl-cyclopropyl)-1,3-bis-(tert-butyl-dimethyl-silanyloxy)-7-hydroxy-4,4,6,8-tetramethyl-undecan-5-one 
• 371785-05-6 (3S,6R,7S,8S)-11-((1R,2R)-2-Benzyloxymethyl-cyclopropyl)-1,3-bis-(tert-butyl-dimethyl-silanyloxy)-7-hydroxy-4,4,6,8-tetramethyl-undecan-5-one 
• 371785-01-2 (3S,6R,7S,8S)-11-((1S,2R)-2-Benzyloxymethyl-cyclopropyl)-3,7-bis-(tert-butyl-dimethyl-silanyloxy)-4,4,6,8-tetramethyl-5-oxo-undecanoic acid methyl ester 
• 371785-07-8 (3S,6R,7S,8S)-11-((1R,2R)-2-Benzyloxymethyl-cyclopropyl)-3,7-bis-(tert-butyl-dimethyl-silanyloxy)-4,4,6,8-tetramethyl-5-oxo-undecanoic acid methyl ester 
• 371785-34-1 [(S)-5-((1S,2R)-2-Benzyloxymethyl-cyclopropyl)-2-methyl-pentyloxy]-tert-butyl-diphenyl-silane 
• 371784-91-7 C₃₁H₄₈O₂Si₂ 
• 371784-92-8 8-(tert-butyl-diphenyl-silanyloxy)-7-methyl-oct-2-yn-1-ol 
• 371784-95-1 (E)-(S)-8-(tert-Butyl-diphenyl-silanyloxy)-7-methyl-oct-2-en-1-ol 
• 371784-93-9 (Z)-(S)-8-(tert-Butyl-diphenyl-silanyloxy)-7-methyl-oct-2-en-1-ol 
• 371784-47-3 Acetic acid (S)-5-((1S,2R)-2-benzyloxymethyl-cyclopropyl)-2-methyl-pentyl ester 

Relevant academic research and scientific papers

The first enantioselective synthesis of palinurin

The first enantioselective synthesis of palinurin has been accomplished starting from commercially available furaldehyde and (R)-methyl-3-hydroxy-2- methylpropionate; the key steps of the synthesis include the use of a chiral pyrrolidine to create the chiral tetronic moiety, and Horner-Wadsworth-Emmons, Wittig and Wittig-Horner reactions to construct the alkene units.

Furan derivatives, method of synthesis and uses thereof

The present invention relates to furan derivatives of formula (I), their method of synthesis and uses thereof. Concretely, the compounds disclosed have proved to be inhibitors of glycogen synthase kinase 3β, GSK-3 β, which is known to be involved in different disease and conditions, such as Alzheimer's disease or non-insulin dependent diabetes mellitus. The present invention also relates to pharmaceutical compositions comprising the same. Further, the present invention is directed to the use of the compounds in the manufacture of a medicament for the treatment and/or prevention of a GSK-3 mediated disease or condition.

Total synthesis of halipeptins: Isolation of halipeptin D and synthesis of oxazoline halipeptin analogues

The isolation from the marine sponge Leiosella cf. arenifibrosa and structural elucidation of halipeptin D (5). a relative of the previously isolated halipeptins A-C (1-3), is described along with the total synthesis of a number of oxazoline analogues (7a

Cyclopropyl and cyclobutyl epothilone analogs

The invention relates to cis- and trans-12, 13-cyclopropyl and 12,13-cyclobutyl epothilones of formula I to IV wherein Ar is a radical represented by the following structure: and the other radicals and symbols have the meanings as defined herein; to their

Chemical synthesis and biological evaluation of cis- and trans-12,13-cyclopropyl and 12,13-cyclobutyl epothilones and related pyridine side chain analogues

The design, chemical synthesis, and biological evaluation of a series of cyclopropyl and cyclobutyl epothilone analogues (3-12, Figure 1) are described. The synthetic strategies toward these epothilones involved a Nozaki - Hiyama - Kishi coupling to form