371975-06-3

Upstream product

• 36805-97-7 N,N-dimethylformamide di-tert-butyl acetal 
• 100-39-0 benzyl bromide 
• 371975-04-1 (1S,2S,4R)-4-Hydroxy-5-oxo-cyclohexane-1,2-dicarboxylic acid di-tert-butyl ester 
• 51096-08-3 (1S,2S)-cyclohex-4-ene-1,2-dicarboxylic acid 
• 221344-09-8 (1S,2S,4R,5S)-4,5-Dihydroxy-cyclohexane-1,2-dicarboxylic acid di-tert-butyl ester 
• 231278-92-5 (1S,2S)-cyclohex-4-ene-1,2-dicarboxylic acid di-tert-butyl ester 

Downstream Products

• 231278-93-6 (1S,2S,4R,5S)-4-Benzyloxy-5-hydroxy-cyclohexane-1,2-dicarboxylic acid di-tert-butyl ester 

Relevant academic research and scientific papers

Stereoselective synthesis of conformationally constrained cyclohexanediols: A set of molecular scaffolds for the synthesis of glycomimetics

The practical, stereoselective synthesis of the three diastereoisomeric 1,2-trans-dicarboxy-4,5-cyclohexanediols 1-3 (DCCHDs) is described, starting from a common precursor, easily available in both enantiomeric forms. The regioselective derivatization of all functional groups of 1 is also reported. The three DCCHDs are locked in a single chair conformation and thus can be used to mimic vicinally disubstituted monosaccharides of any relative configuration.