372-66-7

Basic information

• Product Name: 6-AMINO-2-METHYL-2-HEPTANOL
• Synonyms: TIMTEC-BB SBB004116;2-Heptanol, 6-amino-2-methyl-;2-Methyl-2-hydroxy-6-aminoheptane;6-amino-2-methyl-2-heptano;heptaminol;6-AMINO-2-METHYL-2-HEPTANOL;Heptaminol (base and/or unspecified salts);2-Methyl-6-aminoheptane-2-ol
• CAS NO: 372-66-7
• Molecular Formula: C₈H₁₉NO
• Molecular Weight: 145.24
• EINECS: 206-758-0
• Mol File: 372-66-7.mol
• Article Data: 8

Chemical Properties

• Melting Point: <25 °C
• Boiling Point: 115 °C (11.2515 mmHg)
• Flash Point: 105.08 °C
• Appearance: Clear colorless/Oily Liquid
• Density: 0.895
• Vapor Pressure: 0.00351mmHg at 25°C
• Refractive Index: 1.455-1.457
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 15.30±0.29(Predicted)
• CAS DataBase Reference: 6-AMINO-2-METHYL-2-HEPTANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 6-AMINO-2-METHYL-2-HEPTANOL(372-66-7)
• EPA Substance Registry System: 6-AMINO-2-METHYL-2-HEPTANOL(372-66-7)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 45-36/37/39-26
• Hazardous Substances Data: 372-66-7(Hazardous Substances Data)

Usage

Description

Heptaminol is an aliphatic amine with cardiotonic and sympathomimetic activities. It decreases the amplitude of peak calcium currents by 30% in isolated guinea pig ventricular myocytes when used at a concentration of 100 μM. Heptaminol inhibits norepinephrine uptake and induces catecholamine release in primary bovine chromaffin cells. It increases blood pressure in cats when administered intravenously at a dose of 15 mg, an effect that can be blocked by reserpine .

Chemical Properties

CLEAR COLOURLESS OILY LIQUID

Uses

Different sources of media describe the Uses of 372-66-7 differently. You can refer to the following data:
1. vasodilator
2. Heptaminol is used in the preparation of drugs for treating cardiovascular and cerebrovascular diseases.

InChI:InChI=1/C8H19NO/c1-7(9)5-4-6-8(2,3)10/h7,10H,4-6,9H2,1-3H3/p+1/t7-/m1/s1

Upstream product

• 352641-49-7 N-(6-methylhept-5-en-2-yl)formamide 
• 165962-54-9 (R)-6-amino-2-methylheptan-2-ol 
• 543-82-8 1,5-dimethylhexylamine 
• 110-93-0 6-Methyl-hept-5-en-2-on 
• 90227-28-4 6-hydroxy-6-methyl-heptan-2-one oxime 

Downstream Products

• 34021-62-0 N-(6-hydroxy-6-methylheptan-2-yl)benzamide 
• 5077-57-6 6-hydroxy-6-methyl-heptan-2-one 

Relevant articles and documents

Electrochemical Ruthenium-Catalyzed C-H Hydroxylation of Amine Derivatives in Aqueous Acid

The development of an electrochemically driven, ruthenium-catalyzed C-H hydroxylation reaction of amine-derived substrates bearing tertiary C-H bonds is described. The reaction is performed under constant current electrolysis in a divided cell to afford alcohol products in yields comparable to those of our previously reported process, which requires the use of stoichiometric H5IO6 for catalytic turnover. With aqueous acid as solvent, the cathodic electrode reaction simply involves the reduction of protons to evolve hydrogen gas. The optimized protocol offers a convenient, efficient, and atom-economical method for sp3-C-H bond oxidation.

Remote C(sp3)-H Oxygenation of Protonated Aliphatic Amines with Potassium Persulfate

This letter describes the development of a method for selective remote C(sp3)-H oxygenation of protonated aliphatic amines using aqueous potassium persulfate. Protonation serves to deactivate the proximal C(sp3)-H bonds of the amine substrates and also renders the amines soluble in the aqueous medium. These reactions proceed under relatively mild conditions (within 2 h at 80 °C with amine as limiting reagent) and do not require a transition metal catalyst. This method is applicable to a variety of types of C(sp3)-H bonds, including 3°, 2°, and benzylic C-H sites in primary, secondary, and tertiary amine substrates.

Hydroquinones

New hydroquinones have the formula: STR1 wherein p is 1 or 2 and q is 0 or 1, provided that p+q is 1 or 2; R is a residue of formula: STR2 wherein Q is (i) -OX or (ii) -PO(OR11)((O)x R11); and salts thereof with organic or inorganic acid bases. The groups X and R11 and x are defined hereinafter. The compounds of formula I are useful as stabilisers in photographic materials.