372109-30-3

Basic information

• Product Name: 1-(2-benzyl-phenyl)-piperidine-2,6-dione
• Synonyms: 1-(2-benzyl-phenyl)-piperidine-2,6-dione
• CAS NO: 372109-30-3
• Molecular Weight: 279.338
• Mol File: 372109-30-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2-benzyl-phenyl)-piperidine-2,6-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-benzyl-phenyl)-piperidine-2,6-dione(372109-30-3)
• EPA Substance Registry System: 1-(2-benzyl-phenyl)-piperidine-2,6-dione(372109-30-3)

Safety Data

• Hazardous Substances Data: 372109-30-3(Hazardous Substances Data)

Upstream product

• 108-55-4 glutaric anhydride, 
• 28059-64-5 2-benzylaniline 

Downstream Products

• 1557-41-1 N-[2-(phenylmethyl)phenyl]formamide 
• 372109-36-9 1-(2-benzyl-phenyl)-6-hydroxy-piperidin-2-one 

Relevant articles and documents

Synthesis of tetracyclic DIBENZO[c,f]azepine and benzo[f]thieno[3,2-c]azepine derivatives via N-acyluminium ion cyclization

Tetracyclic dibenzo[c,f]-4-oxopyrrolo[1,2-c]azepine (2a), dibenzo[c,f]-5-oxopiperido[1,2-c]azepine (2b), benzo[f]-4-oxopyrrolo[1,2-a]thieno[3,2-c]azepine (2c), and benzo[f]-5-oxopiperido[1,2-a]thieno[3,2-c]azepine (2d) were prepared through intramolecular N-acyliminium ion cyclization of hydroxylactams (3a-d) with aromatic or heteroaromatic rings such as benzene and thiophene as a π-nucleophile. In the case of furan ring, the hydroxylactams (3e, f) were completely decomposed under the acidic conditions (formic acid or methanesulfonic acid). Subsequent reduction of 2a-d with BF3·O(C2H5)2 and BH3·S(CH3)2 finally provided the tetracyclic dibenzo[c,f]pyrrolo[1,2-c]azepine (1a), dibenzo[c,f]piperido[1,2-c]azepine (1b), benzo[f]pyrrolo[1,2-a]thieno[3,2-c]azepine (1c), and benzo[f]piperido[1,2-a]thieno[3,2-c]azepine derivatives (1d) as analogues of mianserin.