372118-67-7

Basic information

• Product Name: 2-AMINOMETHYLPYRIMIDINE HYDROCHLORIDE
• Synonyms: 2-AMINOMETHYLPYRIMIDINE HYDROCHLORIDE;2-Aminomethylpyrimidine HCl;2-(Aminoethyl)pyrimidinehydrochloride;2-AMINOMETHYLPYRIMIDINEMONOHYDRATECHLORIDE;pyriMidin-2-ylMethanaMine hydrochloride;pyriMidin-2-ylMethanaMine;2-PyriMidineMethanaMine, hydrochloride;2-AMinoMethylpyriMidine h...
• CAS NO: 372118-67-7
• Molecular Formula: C₅H₇N₃*ClH
• Molecular Weight: 145.59
• EINECS: -0
• Mol File: 372118-67-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 218.7 °C at 760 mmHg
• Flash Point: 86.1 °C
• Appearance: /
• Vapor Pressure: 0.102mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 2-AMINOMETHYLPYRIMIDINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINOMETHYLPYRIMIDINE HYDROCHLORIDE(372118-67-7)
• EPA Substance Registry System: 2-AMINOMETHYLPYRIMIDINE HYDROCHLORIDE(372118-67-7)

Safety Data

• Hazardous Substances Data: 372118-67-7(Hazardous Substances Data)

Usage

Description

2-Aminomethylpyrimidine (hydrochloride) is a synthetic intermediate useful for pharmaceutical synthesis.

Uses

2-Pyrimidinemethanamine Hydrochloride is a reagent and an intermediate that is used for pharmaceutical synthesis such as spirocyclic acylguanidines as beta-secretase inhibitors for treatment of neurodegenerative disorders.

InChI:InChI=1/C5H7N3.ClH/c6-4-5-7-2-1-3-8-5;/h1-3H,4,6H2;1H

Upstream product

• 1260843-26-2 tert-butyl (pyrimidin-2-ylmethyl)carbamate 
• 14080-23-0 2-cyanopyrimidine 

Downstream Products

• 330784-47-9 avanafil 
• 1621482-78-7 tert-butyl 2-(hydroxymethyl)-2-((pyrimidin-2-ylmethyl)carbamoyl)pyrrolidine-1-carboxylate 

Relevant articles and documents

Synthesis method of 2-amino methyl pyrimidine hydrochloride and derivatives thereof

The invention relates to preparation of one medicine intermediate, in particular relates to a preparation method of 2-aminomethylpyrimidine hydrochloride and derivatives thereof. The preparation method is improved by overcoming the defects of an industrial production technology and a laboratory technology which are commonly used at present, improvements are as follows: the method takes 2-cyanopyrimidine and derivatives thereof as starting materials, Boc anhydride is adopted as a protective agent, reduction-protection one-pot reaction is carried out under alkaline condition, and then hydrogen chloride deprotection is carried out, so that the 2-aminomethylpyrimidine hydrochloride and the derivatives thereof are prepared. According to the method provided by the invention, the reaction period is short, the conversion rate is high, the product quality is good, and the content of the produced 2-aminomethylpyrimidine hydrochloride and the derivatives thereof is more than 99%; meanwhile, operation steps are simple, required equipment is simple, and energy consumption is low.

PROCESS FOR THE PREPARATION OF (S)-4-[(3-CHLORO-4-METHOXYBENZYL)AMINO]-2-[2- (HYDROXYMETHYL)-1-PYRROLIDINYL]-N-(2-PYRIMIDINYL METHYL-5-PYRIMIDINE CARBOXAMIDE

The present invention relates to an improved process for the preparation of (S)-4-[(3- chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinyl ethyl)- 5-pyrimidine carboxamide compound of formula-1 represented by the following structural formula.

AZINYL IMIDAZOAZINE AND AZINYL CARBOXAMIDE

Azinyl imidazoazines of formula (I), in which the symbols have the meanings indicated in the description, are disclosed, as well as their salts and N oxides, processes for producing the same and new intermediate products. The use of the compounds of formula I and of the intermediate products for combating animal pests and undesirable micro-organisms is also disclosed.