372147-50-7

Basic information

• Product Name: Imidazo[1,2-a]pyridine-5-carboxaldehyde (9CI)
• Synonyms: Imidazo[1,2-a]pyridine-5-carboxaldehyde (9CI);IMidazo[1,2-a]pyridine-5-carboxaldehyde;Imidazo[1,2-a]pyridine-5-carbaldehyde
• CAS NO: 372147-50-7
• Molecular Formula: C8H6N2O
• Molecular Weight: 146.14604
• Product Categories: AMINETERTIARY;ALDEHYDE
• Mol File: 372147-50-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 123-126°C
• Appearance: /
• Density: 1.25 g/cm³
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 4.75±0.50(Predicted)
• CAS DataBase Reference: Imidazo[1,2-a]pyridine-5-carboxaldehyde (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Imidazo[1,2-a]pyridine-5-carboxaldehyde (9CI)(372147-50-7)
• EPA Substance Registry System: Imidazo[1,2-a]pyridine-5-carboxaldehyde (9CI)(372147-50-7)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 372147-50-7(Hazardous Substances Data)

Usage

General Description

Imidazo[1,2-a]pyridine-5-carboxaldehyde (9CI) is a chemical compound with the molecular formula C8H6N2O. It is a heterocyclic compound that contains both imidazole and pyridine rings, making it a potential candidate for various pharmaceutical applications. This chemical has demonstrated anti-cancer and anti-inflammatory properties in scientific studies, and it has also been investigated for its potential role in the treatment of neurodegenerative diseases. Imidazo[1,2-a]pyridine-5-carboxaldehyde (9CI) has also been studied for its use in organic synthesis as a building block for the preparation of other complex chemical compounds. Overall, its unique structure and potential therapeutic properties make it an interesting subject of research in the fields of medicinal chemistry and drug discovery.

Upstream product

• 167884-17-5 5-hydroxymethylimidazo[1,2-a]pyridine 
• 69142-64-9 ethyl 6-aminopicolinate 
• 177485-39-1 ethyl (imidazo[1,2-a]pyridin-5-yl)carboxylate 

Downstream Products

• 372147-66-5 (Z)-ethyl α-[(triphenylphosphoranylidene)amino]-β-(imidazo[1,2-a]pyridin-5-yl)propenoate 
• 429690-44-8 3-nitroimidazo[1,2-a]pyridine-5-carbaldehyde 
• 429690-43-7 3-bromoimidazo[1,2-a]pyridine-5-carbaldehyde 

Relevant articles and documents

BENZISOXAZOLE COMPOUND

Disclosed is a compound represented by the general formula (I) or a salt thereof: wherein any one of R1, R2 and R3 represents a group represented by the formula: -(CH2)m-NR11R12 (wherein m is 1 or 2; and R11 and R12 independently represent a hydrogen atom or a C1-6 alkyl group or may, together with a nitrogen atom to which R11 and R12 are bound, form a 4- or 5-membered cyclic group); the remaining two or R1, R2 and R3 independently represent a group represented by the formula: -(O)n-R21 (wherein n is 0 or 1; and R21 represents a hydrogen atom, a C1-6 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, or the like); and R4 represents a C1-6 alkyl group which may have a substituent or the like.

Heterocyclization of functionalized vinylic derivatives of imidazo[1,2-α]pyridines

Heterocyclization of functionalized vinylic derivatives of imidazo[1,2-α]pyridines was explored experimentally and theoretically using semiempirical AM1 and ab initio methods. A range of functionalized vinylic derivatives (azido, amino, and carbodiimide groups) were prepared for conversion into pyrroloazaindoles 19-22, imidazo[1,x]-; (x=5, 6, 7, 8), [2,6]-, and [2,7]naphthyridines 28-30, 35-38 by thermal reaction. In the case of vinylic groups in the 5 position, peri annulation also was observed. The experimental and theoretical data are compared and discussed.