372159-49-4

Upstream product

• 102308-32-7 (4S)-4-formyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 57234-28-3 1-methoxy-3-(methoxymethoxy)benzene 
• 6160-65-2 1,1'-Thiocarbonyldiimidazole 
• 372159-47-2 tert-butyl (4S)-4-[hydroxy(2-methoxy-6-(methoxymethoxy)phenyl)methyl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate 

Downstream Products

• 372159-52-9 tert-butyl 1-hydroxy-3-(2-hydroxy-6-methoxyphenyl)propan-2-ylcarbamate 
• 372159-50-7 tert-butyl (4R)-4-[2-methoxy-6-(methoxymethoxy)benzyl]-2,2-dimethyl-1,3-oxazolidine 

Relevant academic research and scientific papers

Synthesis of enantiomerically pure 3-aminochroman derivatives

Enantiomerically pure (3R)-amino-5-methoxy-3,4-dihydro-2H-1-benzopyran was successfully synthesised in nine steps starting from L-serine. The same synthetic pathway was used to prepare the (3S)-aminochroman derivative starting from D-serine. The enantiomeric purity of the final aminochroman derivatives was determined by capillary electrophoresis using β-cyclodextrin as the chiral selector.