372162-71-5

Upstream product

• 259862-18-5 6-bromo-3-methyl-1-(2-methylpropyl)-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione 
• 447-61-0 2-Trifluoromethylbenzaldehyde 
• 216686-77-0 3-methyl-1-(2-methylpropyl)-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione 

Downstream Products

• 372162-73-7 5-bromo-1-isobutyl-3-methyl-6-[2-(trifluoromethyl)benzyl]-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione 
• 372162-74-8 5-Bromo-3-methyl-1-(2-methylpropyl)-6-[2-(trifluoromethyl)benzoyl]-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione 
• 901120-83-0 5-cyclohexylsulfanyl-6-[hydroxy-(2-trifluoromethyl-phenyl)-methyl]-1-isobutyl-3-methyl-1H-thieno[2,3-d]pyrimidine-2,4-dione 
• 901120-41-0 5-cyclohexylsulfanyl-1-isobutyl-3-methyl-6-(2-trifluoromethyl-benzoyl)-1H-thieno[2,3-d]pyrimidine-2,4-dione 
• 901120-37-4 5-cyclopentylsulfanyl-1-isobutyl-3-methyl-6-(2-trifluoromethyl-benzoyl)-1H-thieno[2,3-d]pyrimidine-2,4-dione 
• 901120-81-8 5-cyclopentylsulfanyl-6-[hydroxy-(2-trifluoromethyl-phenyl)-methyl]-1-isobutyl-3-methyl-1H-thieno[2,3-d]pyrimidine-2,4-dione 
• 873327-68-5 5-(3-hydroxy-propylsulfanyl)-1-isobutyl-3-methyl-6-(2-trifluoromethyl-benzoyl)-1H-thieno[2,3-d]pyrimidine-2,4-dione 
• 873327-69-6 5-(3-hydroxy-propylsulfanyl)-6-[hydroxy-(2-trifluoromethyl-phenyl)-methyl]-1-isobutyl-3-methyl-1H-thieno[2,3-d]pyrimidine-2,4-dione 

Relevant academic research and scientific papers

Potent blockers of the monocarboxylate transporter MCT1: Novel immunomodulatory compounds

A novel series of potent blockers of the monocarboxylate transporter, MCT1, is disclosed. From very potent but lipophilic lead compounds, systematic changes to all parts of the molecule, targeting reduction in log D, afforded compounds with significantly

Thieno[2,3-d]pyrimidinediones and their use as pharmaceuticals

The invention provides thieno[2,3-d]pyrimidinediones of general formula (I), wherein R, R1, R2 and R3 are as defined in the specification, processes for their production, pharmaceutical compositions containing them and the

Novel compounds

The invention provides thieno[2,3-d]pyrimidinediones of general formula wherein R, R1, R2 and R3 are as defined in the specification, processes for their production, pharmaceutical compositions containing them and their us