3724-66-1

Upstream product

• 590-14-7 1-bromo-1-propene 
• 5764-82-9 bromo(2-ethoxy-2-oxoethyl)zinc 
• 4784-77-4 (E/Z)-crotyl bromide 
• 64-17-5 ethanol 
• 201230-82-2 carbon monoxide 
• 563-52-0 2-chloro-3-butene 
• 591-97-9 1-chloro-2-butene 
• 141-82-2 malonic acid 
• 123-38-6 propionaldehyde 
• 108-29-2 5-methyl-dihydro-furan-2-one 

Downstream Products

• 876143-40-7 (E)-3-Oxo-2-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-hept-5-enenitrile 

Relevant academic research and scientific papers

A PROCESS FOR THE PREPARATION OF AN ALKYL ALKENOATE

A process for the preparation of an alkyl alkenoate, wherein a lactone of the general molecular formula (I) wherein n is 1, 2 or 3, R1 is a C1-C4 alkyl group, and R2, R3 and R4 are, independently, a H atom or a C1-C4 alkyl group, is reacted with a C1-C4 alkyl alcohol in a liquid phase in the presence of a strong acid catalyst at transesterification conditions to form the alkyl alkenoate, wherein alkyl alkenoate and alcohol are continuously removed from the liquid phase by distillation.

Carbonylation of Organic Halides catalysed by Rhodium Triethylphosphine Complexes

Allyl and benzyl halides but not phenyl or propyl halides have been carbonylated in ethanol in the presence of rhodium triethylphosphine complexes to their respective butenoic or benzylic esters; no added base was required.

Temperature-Dependent Alkylation of γ-Phenyl β,γ-Unsaturated Acid and Ester Systems in Hexamethylphosphortriamide-Tetrahydrofuran Solutions Using Lithium Diisopropylamide

The reactivities of some β,γ-unsaturated carboxylic acids and their methyl esters toward alkylation with methyl iodide using the lithium diisopropylamide-hexamethylphosphortriamide (LDA-HMPT) systems in THF have been investigated.The methylation selectivity of pent-3-enoic acid (2) and (1,2-dihydro-3-naphtyl)acetic acid (6) on using 1.0 equiv. of methyl iodide is high, the α-mono- to α,α-dimethylation ratios at -78 deg C being >20.The selectivity is substantially lower for styrylacetic acid (4) and increases with increasing temperature from 2.3 at -78 deg C to 8.5 at -10 deg C.The occurrence of dimethylation is ascribed to intermolecular proton exchange between the monomethylated species IIa and the nonmethylated species Ia.For the β,γ-unsaturated esters the methylation selectivity is somewhat higher than that for the corresponding carboxylic acids.

SUBSTITUTION NUCLEOPHILE VINYLIQUE PAR LE REACTIF DE REFORMATSKY CATALYSSE PAR DES COMPLEXES DU NICKEL ET DU PALLADIUM ZEROVALENTS. SYNTHESE D'ESTERS β,γ-ETHYLENIQUES

Zerovalent complexes of palladium and nickel catalyse vinylic nucleophilic substitution by the Reformatsky reagent giving β,γ-ethylenic esters.Formation of a ?-vinylpalladium complex is the rate-determining step of the reaction.