372515-38-3Relevant articles and documents
Pentopyranosyl oligonucleotide systems: The α-L-lyxopyranosyl-(4′ → 2′)-oligonucleotide system
Reck, Folkert,Wippo, Harald,Kudick, Rene,Krishnamurthy, Ramanarayanan,Eschenmoser, Albert
, p. 1778 - 1804 (2001)
To determine whether the remarkable chemical properties of the pyranosyl isomer of RNA as an informational Watson-Crick base-pairing system are unique to the pentopyranosyl-(4′ → 2′)-oligonucleotide isomer derived from the RNA-building block D-ribose, studies on the entire family of diastereoisomeric pyranosyl-(4′ → 2′)-oligonucleotide systems deriving from D-ribose, L-lyxose, D-xylose, and L-arabinose were carried out. The result of these extended studies is unambiguous: not only pyranosyl-RNA, but all members of the pentopyranosyl-(4′ → 2′)-oligonucleotide family are highly efficient Watson-Crick base-pairing systems. Their synthesis and pairing properties will be described in a series of publications in this journal. The present paper describes the α-L-lyxopyranosyl-(4′ → 2′)-system.
BIARYL AMIDES WITH MODIFIED SUGAR GROUPS FOR TREATMENT OF DISEASES ASSOCIATED WITH HEAT SHOCK PROTEIN PATHWAY
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Page/Page column 153; 180; 200, (2019/12/04)
Provided are biaryl amides and coumarin-based compounds with modified sugar groups for treatment of diseases associated with heat shock protein pathway. The compounds having the following formulas, wherein variables are as defined herein. Formulae (I), (II), (III), (IV), and (V), Pharmaceutical compositions of the compounds are also provided. These biaryl amides and coumarin-based derivatives with modified sugar groups are useful for treatment and prevention of diseases and disorders, including neurological disorders, such as neurodegenerative diseases and nerve damaging disorders, for example, diabetic peripheral neuropathy.