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(2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanonehydrochloride is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

372523-75-6

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372523-75-6 Usage

Uses

TCS OX2 29 is a potent and selective orexin-2 receptor (OX2) antagonist.

Check Digit Verification of cas no

The CAS Registry Mumber 372523-75-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,7,2,5,2 and 3 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 372523-75:
(8*3)+(7*7)+(6*2)+(5*5)+(4*2)+(3*3)+(2*7)+(1*5)=146
146 % 10 = 6
So 372523-75-6 is a valid CAS Registry Number.
InChI:InChI=1/C23H31N3O3/c1-23(2,3)21(25-14-16-6-9-24-10-7-16)22(27)26-11-8-17-12-19(28-4)20(29-5)13-18(17)15-26/h6-7,9-10,12-13,21,25H,8,11,14-15H2,1-5H3/t21-/m1/s1

372523-75-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name TCS OX2 29,(2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanonehydrochloride

1.2 Other means of identification

Product number -
Other names 8-Bromo-cGMP,sodium salt

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:372523-75-6 SDS

372523-75-6Downstream Products

372523-75-6Relevant academic research and scientific papers

N-Acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: The first orexin-2 receptor selective non-peptidic antagonist

Hirose, Masaaki,Egashira, Shin-Ichiro,Goto, Yasuhiro,Hashihayata, Takashi,Ohtake, Norikazu,Iwaasa, Hisashi,Hata, Mikiko,Fukami, Takehiro,Kanatani, Akio,Yamada, Koji

, p. 4497 - 4499 (2003)

The identification of potent and selective orexin-2 receptor (OX 2R) antagonists is described based on the modification of N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline analogue 1, recently discovered during high throughput screening (HTS). Substitution of an acyl group in 1 with tert-Leucine (tert-Leu), and introduction of a 4-pyridylmethyl substituent onto the amino function of tert-Leu improved compound potency, selectivity, and water solubility. Thus, compound 29 is a promising tool to investigate the role of orexin-2 receptors.

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