372944-87-1

Basic information

• Product Name: methyl 3-(3-methoxyphenyl)-4-nitrobutanoate
• Synonyms: methyl 3-(3-methoxyphenyl)-4-nitrobutanoate
• CAS NO: 372944-87-1
• Molecular Weight: 253.255
• Mol File: 372944-87-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl 3-(3-methoxyphenyl)-4-nitrobutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-(3-methoxyphenyl)-4-nitrobutanoate(372944-87-1)
• EPA Substance Registry System: methyl 3-(3-methoxyphenyl)-4-nitrobutanoate(372944-87-1)

Safety Data

• Hazardous Substances Data: 372944-87-1(Hazardous Substances Data)

Upstream product

• 591-31-1 3-methoxy-benzaldehyde 
• 1267018-21-2 C₁₁H₁₃NO₅ 
• 18107-18-1 diazomethyl-trimethyl-silane 

Downstream Products

• 1056971-34-6 N-benzyl-3-(3-methoxyphenyl)pyrrolidine 
• 38175-34-7 4-(3-methoxyphenyl)pyrrolidin-2-one 
• 38175-35-8 3-(3-methoxyphenyl)pyrrolidine 

Relevant articles and documents

Synthesis of 3-(3-hydroxyphenyl)pyrrolidine dopamine D3 receptor ligands with extended functionality for probing the secondary binding pocket

A series of 3-(3-hydroxyphenyl)pyrrolidine analogues which incorporate N-alkyl groups and N-butylamide-linked benzamide functionality have been synthesized and their in vitro binding affinities at human dopamine receptors have been evaluated. Our ligand design strategy was to take the 3-(3-hydroxyphenyl)pyrrolidine scaffold and extend functionality from the orthosteric binding site to the secondary binding pocket for enhancing affinity and selectivity for the D3 receptor. The N-alkyl analogues constitute a homologous series from N-pentyl to N-decyl to probe the length/bulk tolerance of the secondary binding pocket of the D3 receptor. Enantiomeric 3-(3-hydroxyphenyl)pyrrolidine analogues were also prepared in order to test the chirality preference of the orthosteric binding site for this scaffold. Benzamide analogues were prepared to enhance affinity and/or selectivity based upon the results of the homologous series.