372965-11-2

Upstream product

• 98-88-4 benzoyl chloride 
• 72030-85-4 4-methoxycarbonyl-5-(1-methylethyl)-1,3-oxazole 

Downstream Products

• 372965-16-7 methyl (4R,5R)-5-isopropyl-2-phenyl-4,5-dihydrooxazole-4-carboxylate 
• 220805-64-1 methyl (4S,5S)-5-isopropyl-2-phenyl-4,5-dihydrooxazole-4-carboxylate 
• 87421-24-7 (-)-(2R,3R)-β-hydroxyleucine 
• 87421-23-6 (2R,3S)-2-amino-3-hydroxy-4-methylpentanoic acid 
• 10148-70-6 (2S,3S)-3-hydroxyleucine 
• 5817-22-1 (2S,3R)-3-hydroxyleucine 
• 220805-63-0 methyl (2S,3R)-2-benzoylamino-3-hydroxy-4-methylpentanoate 
• 220805-68-5 (2R,3S)-2-benzoylamino-3-hydroxy-4-methylpentanoic acid methyl ester 

Relevant academic research and scientific papers

Efficient enantioselective synthesis of (2R,3R)- and (2S,3S)-3-hydroxyleucines and their diastereomers through dynamic kinetic resolution

(2R,3R)- and (2S,3S)-3-Hydroxyleucines, components of cyclodepsipeptides, papuamides and polyoxypeptins, were efficiently synthesized along with their diastereomers from the corresponding β-keto-α-amino acid ester through dynamic kinetic resolution using RuCl2(binap)-catalyzed hydrogenation.

Rhodium-mediated asymmetric transfer hydrogenation: A diastereo- and enantioselective synthesis of: Syn -α-amido β-hydroxy esters

The preparation of syn α-benzoylamido β-hydroxy esters through asymmetric transfer hydrogenation (ATH) with a tethered Rh(iii)-DPEN complex via dynamic kinetic resolution (DKR) has been developed for the first time starting from α-benzoylamido β-keto esters. A variety of α-benzoylamido β-keto esters were converted under mild conditions into the corresponding syn α-benzoylamino β-hydroxy esters with high yields (up to 98%) and diastereomeric ratios (up to >99:1 dr) as well as excellent enantioselectivities (up to >99% ee).