372982-57-5Relevant articles and documents
Novel non-covalent thrombin inhibitors incorporating P1 4,5,6,7-tetrahydrobenzothiazole arginine side chain mimetics
Marinko, Petra,Krbavcic, Ales,Mlinsek, Gregor,Solmajer, Tomaz,Bakija, Alenka Trampus,Stegnar, Mojca,Stojan, Jure,Kikelj, Danijel
, p. 257 - 265 (2007/10/03)
The design, synthesis and biological activity of a series of novel non-covalent D-Phe-Pro-Arg motif-based thrombin inhibitors incorporating 4,5,6,7-tetrahydrobenzothiazol-2-amine as a novel arginine surrogate are described. Compound 9, the most potent in