373-16-0

Basic information

• Product Name: 6-fluorohex-1-yne
• Synonyms: 1-hexyne, 6-fluoro-; 6-Fluorohex-1-yne
• CAS NO: 373-16-0
• Molecular Formula: C₆H₉F
• Molecular Weight: 100.1341
• Mol File: 373-16-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 90.2°C at 760 mmHg
• Flash Point: 9.6°C
• Density: 0.857g/cm³
• Vapor Pressure: 64mmHg at 25°C
• Refractive Index: 1.392
• CAS DataBase Reference: 6-fluorohex-1-yne(CAS DataBase Reference)
• NIST Chemistry Reference: 6-fluorohex-1-yne(373-16-0)
• EPA Substance Registry System: 6-fluorohex-1-yne(373-16-0)

Safety Data

• Hazardous Substances Data: 373-16-0(Hazardous Substances Data)

Upstream product

• 76911-01-8 5-hexynyl p-toluenesulfonate 
• 462-73-7 1-chloro-4-fluorobutane 
• 70277-75-7 lithium acetylide 
• 10297-06-0 1-chloro-5-hexyne 
• 372-91-8 1-fluoro-4-iodobutane 
• 1066-26-8 sodium acetylide 

Relevant articles and documents

N-Succinimidyl 3-((4-(4-[18F]fluorobutyl)-1H-1,2,3-triazol-1-yl)methyl)-5-(guanidinomethyl)benzoate ([18F]SFBTMGMB): A residualizing label for 18F-labeling of internalizing biomolecules

Residualizing labeling methods for internalizing peptides and proteins are designed to trap the radionuclide inside the cell after intracellular degradation of the biomolecule. The goal of this work was to develop a residualizing label for the 18F-labeling of internalizing biomolecules based on a template used successfully for radioiodination. N-Succinimidyl 3-((4-(4-[18F]fluorobutyl)-1H-1,2,3-triazol-1-yl)methyl)-5-(bis-Boc-guanidinomethyl)benzoate ([18F]SFBTMGMB-Boc2) was synthesized by a click reaction of an azide precursor and [18F]fluorohexyne in 8.5 ± 2.8% average decay-corrected radiochemical yield (n = 15). An anti-HER2 nanobody 5F7 was labeled with 18F using [18F]SFBTMGMB ([18F]RL-I), obtained by the deprotection of [18F]SFBTMGMB-Boc2, in 31.2 ± 6.7% (n = 5) conjugation efficiency. The labeled nanobody had a radiochemical purity of >95%, bound to HER2-expressing BT474M1 breast cancer cells with an affinity of 4.7 ± 0.9 nM, and had an immunoreactive fraction of 62-80%. In summary, a novel residualizing prosthetic agent for labeling biomolecules with 18F has been developed. An anti-HER2 nanobody was labeled using this prosthetic group with retention of affinity and immunoreactivity to HER2.