373-28-4

Usage

Uses

Used in Polymer Synthesis:
BRN 1697301 is used as a monomer in the synthesis of polymer materials, particularly for the development of hydrogels. These hydrogels have diverse applications in the biomedical field due to their biocompatibility, tunable properties, and ability to mimic the extracellular matrix.
Used in Drug Delivery Systems:
BRN 1697301 is utilized as a component in drug delivery systems, where its unique properties can enhance the delivery, bioavailability, and therapeutic outcomes of various drugs. Its potential as a carrier for drug molecules allows for controlled and targeted release, improving the efficacy and safety of drug administration.
Used in Tissue Engineering and Regenerative Medicine:
In the field of tissue engineering and regenerative medicine, BRN 1697301 is employed as a material for scaffolds and matrices that support cell growth, differentiation, and tissue regeneration. Its biocompatibility and ability to integrate with biological systems make it a valuable tool for creating functional and durable tissue replacements.
Used in Biomedical Applications:
BRN 1697301 is used in various biomedical applications, such as diagnostic tools, sensors, and imaging agents, due to its unique chemical and physical properties. Its versatility allows for the development of innovative solutions to address complex medical challenges and improve patient outcomes.

InChI:InChI=1/C6H12BrF/c7-5-3-1-2-4-6-8/h1-6H2

Upstream product

• 373-32-0 6-fluoro-hexan-1-ol 
• 4286-55-9 1-bromo-6-hexanol 
• 629-03-8 1 ,6-dibromohexane 

Downstream Products

• 408-15-1 8-fluoro-oct-1-yne 
• 88746-44-5 1-<(2-Tetrahydropyranyl)oxy>-10-fluorodec-3-yne 
• 408-09-3 6-fluoro-hexane-1-thiol 
• 1120341-48-1 (6-fluorohexyl)benzene 
• 847672-50-8 (R/S)-(4-{2-[4-(6-fluoro-hexyloxy)-phenyl]-ethyl}-2-methyl-4,5-dihydro-oxazol-4-yl)-methanol 
• 3109-58-8 16-fluorohexadecanoic acid 
• 353-21-9 1-Amino-7-fluoroheptane 
• 374109-22-5 (2-{2-[4-(6-fluoro-hexyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl]-ethoxy}-phenyl)-acetic acid methyl ester 
• 408-08-2 1-fluoro-6-nitro-hexane 
• 408-28-6 6-fluoro-hexylsulfanyl cyanate 
• 334-44-1 7-Fluoroheptanenitrile 

Relevant academic research and scientific papers

C-F bond substitution via aziridinium ion intermediates

Aliphatic 1,2-aminofluorides undergo extremely fast substitution reactions under the influence of lanthanum tris(hexamethyldisilazide). The substitution proceeds via an in situ generated aziridinium ion intermediate, which subsequently undergoes ring opening by addition of a nucleophile, yielding various β-substituted amines.

Biologically active 4H-benzo [1,4] oxazin-3-ones

The invention is directed to 4h-benzo[1,4]oxazin-3-ones useful as peroxisome proliferator activated receptor gamma (PPARγ) agonists or antagonists. Pharmaceutical compositions comprising compounds of the present invention and methods of treating conditions such as NIDDM and obesity are also disclosed.

Benzoxazinones as PPARγ Agonists. 2. SAR of the Amide Substituent and In Vivo Results in a Type 2 Diabetes Model

A series of benzoxazinones has been synthesized and tested for PPARγ agonist activity. Synthetic approaches were developed to provide either racemic or chiral compounds. In vitro functional potency could be measured through induction of the aP2 gene, a target of PPARγ. These studies revealed that compounds with large aliphatic chains at the nitrogen of the benzoxazinone were the most potent. Substitution of the chain was tolerated and in many cases enhanced the in vitro potency of the compound. Select compounds were further tested for metabolic stability, oral bioavailability in rats, and efficacy in db/db mice after 11 days of dosing. In vivo analysis with 13 and 57 demonstrated that the series has potential for the treatment of type 2 diabetes.

Biologically active 4H-benzo [1,4] oxazin-3-ones

The invention is directed to 4h-benzo[1,4]oxazin-3-ones useful as peroxisome proliferator activated receptor gamma (PPARgamma) agonists or antagonists. Pharmaceutical compositions comprising compounds of the present invention and methods of treating conditions such as NIDDM and obesity are also disclosed.

Biologically active 4H-benzo [1,4]oxazin-3-ones

The invention is directed to 4h-benzo[1,4]oxazin-3-ones useful as peroxisome proliferator activated receptor gamma (PPARγ) agonists or antagonists. Pharmaceutical compositions comprising compounds of the present invention and methods of treating conditions such as NIDDM and obesity are also disclosed.

Approaches towards the synthesis of fluoro(cyclo)alkylamines

The synthesis of fluoro(cyclo)alkylamines 1-amino-6-fluorohexane (1), 1-amino-7-fluoroheptane (2), cis/trans-4-fluorocyclohexylamine (3a,b) and cis-4-fluoromethylcyclohexylamine (4) has been investigated for use as synthons for histamine receptor ligands for use in PET.

FLUORINATION OF HALOGENO ALCOHOLS WITH 1,1,2,3,3,3-HEXAFLUOROPROPYL DIETHYLAMINE

Fluorination of halogeno alcohols with 1,1,2,3,3,3-hexafluoropropyl diethylamine (PPDA) was investigated. 2-Bromo-1-fluorobutane was obtained from the reaction of PPDA and 2-bromo-1-butanol (yield 50percent).Similar results were obtained from other alipha

Synthesis of ω-Tritiated and ω-Fluorinated Analogues of the Trail Pheromone of Subterranean Termites

A series of unsaturated ω-fluoro alcohols have been prepared stereoselectively.These simple compounds are structural analogues of the trail pheromone of termites in the genus Reticulitermes.The toxicity of these ω-fluoro alcohols to R. flavipes is maximal for the C12 alcohols, and the attractiveness of these C12 analogues increases in the order saturated alkanol -12-fluoro alcohols and a -nonfluorinated analogue were prepared to examine the catabolism of the pheromone analogues.

Attractant termiticidal compounds, compositions and methods of use therefor

Alpha - fluoro - omega - hydroxy straight chain hydrocarbons are utilized to form attractant termiticidal compositions which are safe and economical for the combatting of termites and related pests.