373-29-5

Usage

Uses

Used in Chemical Synthesis:
1,6-difluorohexane is utilized as a solvent or intermediate in various chemical reactions, facilitating the synthesis of a range of compounds due to its unique chemical properties.
Used in Refrigeration Industry:
1,6-difluorohexane is considered for use as a refrigerant, leveraging its low boiling point and non-toxic nature to provide an alternative to traditional refrigerants, while still being mindful of its environmental classification as a VOC and potential greenhouse gas.
Used in Environmentally Conscious Applications:
Given its categorization as a VOC and potential greenhouse gas, 1,6-difluorohexane is used with the aim of developing more environmentally friendly processes and products, ensuring that its production and application adhere to strict regulations to minimize adverse effects on the environment and human health.

Upstream product

• 2163-00-0 1,6-dichlorohexane 
• 107-21-1 ethylene glycol 
• 629-11-8 1,6-hexanediol 

Downstream Products

• 1595-01-3 1-hexyl-4-methyl-benzene 
• 124778-32-1 1,6-di(p-tolyl)hexane 

Relevant academic research and scientific papers

A useful conversion of alcohols to alkyl fluorides

A useful conversion of alcohols to alkyl fluorides via their fluoroformates is introduced. The fluoroformates are obtained in nearly quantitative yield from the alcohols by treatment with COF2 (generated in situ from bis(trichloromethyl) carbonate) in ether with KF as an added acid scavenger. The neat fluoroformates are cleaved to the fluorides by heating at 120-125°C using hexabutylguanidinium fluoride (HBGF) as the catalyst.

Deiodinative fluorination of alkyl iodide with p-iodotoluene difluoride

Oxidative fluorination of alkyl iodides with p-iodotoluene difluoride (4) was carried out. In the presence of Et3N-4HF, the fluorination reaction of prim-alkyl iodides selectively took place at the iodine position under mild conditions to give the corresponding alkyl fluorides in good yields.

Reaction of diethylaminosulfur trifluoride with diols

Diethylaminosulfur trifluoride (DAST) reacts with dialcohols to give difluorides, sulfite esters or cyclic ethers depending on the number of carbons separating the two alcohol groups.Vicinal and 1,3-diols give large amounts of sulfite ester products while butane-1,4-diol gives almost exclusively the cyclic ether tetrahydrofuran.Terminal dialcohols longer than four carbons give primarily difluoride products.Semiempirical calculations indicate a preference for cyclic intermediates when four or less carbons separate the two alcohol moieties.These cyclic intermediates lead directly to the cyclic ethers and sulfite ester products.