373-29-5

Basic information

• Product Name: 1,6-difluorohexane
• Synonyms: 1,6-difluorohexane
• CAS NO: 373-29-5
• Molecular Formula: C₆H₁₂F₂
• Molecular Weight: 122.1562864
• Mol File: 373-29-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 117.34°C (rough estimate)
• Appearance: /
• Density: 0.9315 (rough estimate)
• Refractive Index: 1.3409 (estimate)
• CAS DataBase Reference: 1,6-difluorohexane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,6-difluorohexane(373-29-5)
• EPA Substance Registry System: 1,6-difluorohexane(373-29-5)

Safety Data

• Hazardous Substances Data: 373-29-5(Hazardous Substances Data)

Usage

General Description

1,6-difluorohexane is a chemical compound with the molecular formula C6H12F2. It is a colorless liquid with a faint odor and is insoluble in water. 1,6-difluorohexane is primarily used as a solvent or intermediate in various chemical reactions. It has also been researched for its potential use as a refrigerant due to its low boiling point and non-toxic nature. However, its production and use may have adverse effects on the environment and human health, as it is categorized as a volatile organic compound (VOC) and a potential greenhouse gas. Therefore, it is important to handle and use 1,6-difluorohexane with proper precautions and in line with regulations to minimize its impact on the environment and human health.

Upstream product

• 107-21-1 ethylene glycol 
• 2163-00-0 1,6-dichlorohexane 
• 629-11-8 1,6-hexanediol 

Downstream Products

• 1595-01-3 1-hexyl-4-methyl-benzene 
• 124778-32-1 1,6-di(p-tolyl)hexane 

Relevant articles and documents

A useful conversion of alcohols to alkyl fluorides

A useful conversion of alcohols to alkyl fluorides via their fluoroformates is introduced. The fluoroformates are obtained in nearly quantitative yield from the alcohols by treatment with COF2 (generated in situ from bis(trichloromethyl) carbonate) in ether with KF as an added acid scavenger. The neat fluoroformates are cleaved to the fluorides by heating at 120-125°C using hexabutylguanidinium fluoride (HBGF) as the catalyst.

Reaction of diethylaminosulfur trifluoride with diols

Diethylaminosulfur trifluoride (DAST) reacts with dialcohols to give difluorides, sulfite esters or cyclic ethers depending on the number of carbons separating the two alcohol groups.Vicinal and 1,3-diols give large amounts of sulfite ester products while butane-1,4-diol gives almost exclusively the cyclic ether tetrahydrofuran.Terminal dialcohols longer than four carbons give primarily difluoride products.Semiempirical calculations indicate a preference for cyclic intermediates when four or less carbons separate the two alcohol moieties.These cyclic intermediates lead directly to the cyclic ethers and sulfite ester products.