373354-37-1Relevant articles and documents
Intermolecular Pauson-Khand reactions of cyclopropane: A general synthesis of cyclopentanones
Marchueta, Iolanda,Verdaguer, Xavier,Moyano, Albert,Pericas, Miquel A.,Riera, Antoni
, p. 3193 - 3196 (2007/10/03)
(equation presented) The Pauson-Khand reaction of cyclopropene with a variety of terminal alkynes has been studied. The best reaction conditions involve NMO activation in CH2Cl2 at -35 °C. In this way, 3-substituted-bicyclo[3.1.0]hex-3-en-2-ones have been obtained in good to excellent yields. As a synthetic application, several types of substituted cyclopentenones have been prepared from these cycloadducts by protocols involving conjugate addition and reductive ring opening.