373384-13-5

Usage

Uses

Used in Pharmaceutical Industry:
4-Chlorophenylboronic Acid Propanediol Ester is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure, including the boronic acid and propanediol components, allows it to participate in specific chemical reactions that are crucial for the development of new drugs.
Used in Chemical Synthesis:
4-Chlorophenylboronic Acid Propanediol Ester is used as a reagent in the synthesis of other chemical compounds. Its 4-chlorophenyl group provides a distinct reactivity that can be exploited in the formation of new molecules, making it a valuable component in the creation of various chemical products.
Used in Research and Development:
4-Chlorophenylboronic Acid Propanediol Ester is used as a research tool in the study of chemical reactions and mechanisms. Its unique properties and reactivity can provide insights into the behavior of similar compounds, contributing to the advancement of chemical knowledge and the development of new synthetic strategies.

InChI:InChI=1/C11H14BClO2/c1-11(2)7-14-12(15-8-11)9-3-5-10(13)6-4-9/h3-6H,7-8H2,1-2H3

Upstream product

• 1679-18-1 4-Chlorophenylboronic acid 
• 504-63-2 trimethyleneglycol 

Downstream Products

• 1370412-43-3 N-((4-chlorophenyl)(phenyl)methyl)-3-methylpyridin-2-amine 
• 1416556-09-6 N-{[4-chlorophenyl](phenyl)methyl}-3-phenylpyridin-2-amine 
• 1416556-13-2 N-[(4-chlorophenyl)(p-tolyl)methyl]-3-methylpyridin-2-amine 
• 127292-04-0 N-(3,5-dimethylphenyl)-4-chlorobenzamide 
• 1431616-03-3 2-(4-chlorophenyl)-1-[3-(trifluoromethyl)pyridin-2-yl]piperidine 
• 1417331-22-6 methyl 4-amino-6-(4-chlorophenyl)-3-methoxypicolinate 

Relevant academic research and scientific papers

Copper(i)-catalyzed amidation reaction of organoboronic esters and isocyanates

A simple and efficient methodology for the preparation of amides from easily available organoboronic esters and isocyanates has been accomplished using a ligand-free copper(i) catalyst. The reaction system demonstrated a broad substrate scope and provided convenient access to a wide variety of secondary amides.

Generation of organolithium compounds bearing super silyl ester and their application to Matteson rearrangement

It's super-silyl-fragilithyl-ester-aryl-docious: The super silyl group is a strong protecting group for carboxylic acids and provides a method for direct lithiation that is compatible with the ester moiety. Organolithium compounds bearing a super silyl ester react with a variety of electrophiles in high yields (see scheme). The reaction of lithiated super silyl chloroacetate with a boron compound gives α-functionalization of the ester moiety by Matteson rearrangement. Copyright

Ruthenium(0)-catalyzed sp3 C-H bond arylation of benzylic amines using arylboronates

A Ru-catalyzed direct arylation of benzylic sp3 carbons of acyclic amines with arylboronates is reported. This highly regioselective and efficient transformation can be performed with various combinations of N-(2-pyridyl) substituted benzylamines and arylboronates. Substitution of the pyridine directing group in the 3-position proved to be crucial in order to achieve high arylation yields. Furthermore, the pyridine directing group can be removed in high yields via a two-step protocol.